Spots Global Cancer Trial Database for Retrospective Study in FFPE Samples From Younger Patients With Rhabdomyosarcoma

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Trial Identification

Brief Title: Retrospective Study in FFPE Samples From Younger Patients With Rhabdomyosarcoma

Official Title: Mechanism of Children With Relapsed and Refractory Rhabdomyosarcoma (RMS)

Study ID: NCT06040229

Conditions

Alveolar Childhood Rhabdomyosarcoma

Embryonal Childhood Rhabdomyosarcoma

Recurrent Childhood Rhabdomyosarcoma

Interventions

Study Description

Brief Summary: This retrospective study is looking into mechanisms of drug therapy resistance in FFPE samples in recurrent and refractory Rhabdomyosarcoma (RMS) in pediatric patients who have experienced lung recurrence. The study employs advanced techniques such as single-cell transcriptomics and spatial transcriptomics to gain a comprehensive understanding of these mechanisms.

Detailed Description: This research seeks to enhance our understanding of drug resistance mechanisms in recurrent and refractory RMS in pediatric patients, particularly in the context of lung recurrence. The utilization of cutting-edge techniques like single-cell transcriptomics and spatial transcriptomics allows for a more in-depth and comprehensive analysis of the molecular and spatial aspects of drug resistance in this challenging pediatric cancer.