Spots Global Cancer Trial Database for Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma

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Trial Identification

Brief Title: Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma

Official Title: Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma

Study ID: NCT01609803

Conditions

Alveolar Childhood Rhabdomyosarcoma

Embryonal Childhood Rhabdomyosarcoma

Previously Treated Childhood Rhabdomyosarcoma

Previously Untreated Childhood Rhabdomyosarcoma

Recurrent Childhood Rhabdomyosarcoma

Interventions

laboratory biomarker analysis

Study Description

Brief Summary: This research trial studies protein expression in tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

Detailed Description: PRIMARY OBJECTIVES: I. To investigate (in two stages) which proteins are overexpressed in association with 12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases organized into tissue microarrays. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC.