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Spots Global Cancer Trial Database for Haploidentical Donor vs mMUD in Hematological Malignancies

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Trial Identification

Brief Title: Haploidentical Donor vs mMUD in Hematological Malignancies

Official Title: A Randomized Controlled Trial Comparing Outcome After Hematopoietic Cell Transplantation From a Partially Matched Unrelated Versus Haploidentical Donor

Study ID: NCT03275636

Conditions

AML
ALL
MDS

Study Description

Brief Summary: The goal of this trial is to compare the outcome after partially matched (single mismatch) unrelated donor transplantation with haploidentical transplantation in a randomized controlled setting.

Detailed Description: For patients with an indication for allogeneic HCT, the search for a stem cell donor is a challenge. 20% of patients who need an allograft have an HLA-identical sibling available, and for approximately 70% of the remaining patients, a suitable, HLA-well-matched (10/10), unrelated volunteer can be found. For the remaining patients, partially matched (single mismatch) unrelated donors or haploidentical donors are alternative options. Recently published retrospective single center and registry studies suggest comparable outcomes for HCT from unrelated donors matched at HLA -A, -B, -C, and -DRB1 and haploidentical donors. The number of haploidentical HCT evaluated in these studies was still relatively small and a selection bias for the retrospective comparisons cannot be excluded. The goal of this trial is to evaluate overall survival of patients with high-risk AML, ALL or MDS after partially matched unrelated or haploidentical donor transplantation..

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Universitätsklinikum Bonn, Bonn, , Germany

Universitätsklinikum Dresden, Dresden, , Germany

Universitätsklinikum Frankfurt, Frankfurt am Main, , Germany

Universitätsklinikum Halle (Saale), Halle, , Germany

Universitätsmedizin Mannheim, Mannheim, , Germany

Universitätsklinikum Mßnster, Mßnster, , Germany

Klinikum NĂźrnberg Nord, NĂźrnberg, , Germany

Robert-Bosch-Krankenhaus, Stuttgart, , Germany

Universitätsklinikum Tßbingen, Tßbingen, , Germany

Contact Details

Name: Johannes Schetelig, Prof Dr med

Affiliation: Universtitätsklinikum Dresden

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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