Spots Global Cancer Trial Database for Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis
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Trial Identification
Brief Title: Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis
Official Title: A Single Arm, Open-Label, Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis
Study ID: NCT05199337
Interventions
Study Description
Brief Summary: This is a single arm, Open-Label, Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis.
Detailed Description: A Single Arm, Open-Label, Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis. The first part of the study is phase 1 dose-escalation and the second part will be phase 2.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Southern California, Los Angeles, California, United States
Colorado Blood Cancer Institute, Denver, Colorado, United States
Tulane University, New Orleans, Louisiana, United States
Washington University, Saint Louis, Missouri, United States
Tennessee Oncology, Nashville, Tennessee, United States
Blackwater (Westmead) Hospital, Westmead, New South Wales, Australia
Princess Alexandra Hospital, Brisbane, Queensland, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Bank of Cyprus Hospital, Nicosia, , Cyprus
National and Kapodistrian University of Athens, Athens, , Greece
Rambam Hospital, Haifa, , Israel
Hadassah Medical Center, Jerusalem, , Israel
Sheba Medical Center, Tel Aviv, , Israel
Tel Aviv Sourasky Medical Center PPDS, Tel Aviv, , Israel
IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola Malpighi, Bologna, , Italy
Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, , Italy
ICO Badalona-H.U. Germans Trias i Pujol, Barcelona, Badalona, Spain
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
Hospital Clinic de Barcelona, Barcelona, , Spain
Clinico de Salamanca, Salamanca, , Spain
Contact Details
Name: Medical Affairs
Affiliation: K-Group Alpha subsidiary of Zentalis Pharmaceuticals
Role: STUDY_DIRECTOR
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