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Brief Title: ART: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy
Official Title: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy
Study ID: NCT02145416
Brief Summary: This is a single arm, single centre imaging study which will be offered to all consecutive, eligible patients receiving radical chemoradiation therapy (CRT) for anal cancer within Oxford University Hospitals. Investigations * Dynamic contrast enhanced magnetic resonance imaging (DCE MRI) * Diffusion weighted magnetic resonance imaging (DWI MRI) * MRI scan designed to measure the T1 or produce T1-weighed images (T1 MRI) * MRI scan designed to measure the T2\* or produce T2\*-weighed images (T2\* MRI) * Perfusion computed tomography (pCT) * Fludeoxyglucose positron emission tomography (FDG PET/CT) Study Design: Observational Target Population: Patients undergoing radical CRT for anal cancer in Oxford University Hospitals National Health Service (NHS) Trust. Duration on study: Patients should be on study for a maximum of 5 months. Patient care post-trial: Follow up as per local standard. No. of Study Site(s): Single Centre, United Kingdon (UK) End of study: Last Patient, last assessment of response. Patients should be on study for a maximum of 5 months.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Churchill Hospital, Oxford, , United Kingdom
Name: Rebecca Muirhead, MBCHB, MRCP, FRCR, MD
Affiliation: Oxford University Hospitals NHS Trust
Role: PRINCIPAL_INVESTIGATOR