Spots Global Cancer Trial Database for Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

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Trial Identification

Brief Title: Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

Official Title: Evaluation of a Causal Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes: A Mendelian Randomization Analysis

Study ID: NCT04743466

Conditions

Anxiety Disorder

Depression

Genetic Disorder

Hematopoietic and Lymphoid Cell Neoplasm

Malignant Solid Neoplasm

Interventions

Electronic Health Record Review

Study Description

Brief Summary: This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.

Detailed Description: PRIMARY OBJECTIVE: I. To use a Mendelian randomization study design to determine whether genetically predicted decreased testosterone levels are associated with an increased risk of dementia. SECONDARY OBJECTIVE: I. To examine whether genetically predicted decreased testosterone levels are associated with worse cognitive function and adverse mental health outcomes. OUTLINE: Patients' records from institutional or national biobanks are reviewed.