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Spots Global Cancer Trial Database for Ritalin: Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients

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Trial Identification

Brief Title: Ritalin: Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients

Official Title: Randomized Study Evaluating the Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients

Study ID: NCT00273741

Study Description

Brief Summary: The aim/objective of this study is to evaluate the antiasthenic effect of methylphenidate with a visual analogical scale (VAS) after 7 days of treatment, in cancer patients, in palliative care, i.e. with a progressive or terminal disease.

Detailed Description: Cancer patients in an advanced phase or who are terminally ill generally present with depression, pain, drowsiness, alterations of cognition, anorexia and other symptoms due to the progressive disease. The objective of the medical team of support and palliative care is to control these effects to maintain a quality of life. Particularly, the cancer patient in an advanced phase of the disease presents with important asthenia. In some patients, this asthenia is characterized by drowsiness or apathy. It always leads to ill-being and a sensation of bad adaptation. When an etiologic treatment is possible (correction of the anaemia, of the metabolic disorders, of the undernutrition, of the anorexia, of the insomnia, of the stubborn pain, of the psychological suffering), the asthenia can be fought. But, when it appears in patients not really in the end of life (life expectancy more than 1 month) and when no etiologic treatments are possible, other solutions must be considered, and all the more when the complaint is important with repeated requests for relief. Methylphenidate is an amphetamine first indicated for deficient attention disorders with hyperactivity in children more than 6 years old. Several studies have been realized to evaluate its effect in cancer patients in palliative care. Some studies showed, in particular, its effectiveness on asthenia because of a stimulant and an antidepressant action. The methylphenidate could have an anti-analgesic effect or co-analgesic effect. All these studies are observational and not randomized. So they have a small level of proof and they have not been realized in a population of asthenic patients in palliative care. So a randomized controlled clinical trial in this specific population needs to be experimented.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hôpital D'Annemasse, Annemasse, , France

Centre Régional d'Accompagnement et de Soins Palliatifs,, Bordeaux, , France

Equipe mobile de recherche et de soutien en soins pallitaifs, Grenoble, , France

Unité de Soins palliatif, Centre Oscar Lambret, Lille, , France

Unité de Soins Palliatifs, Hôpital Lyon sud, Lyon, , France

Soins Palliatifs et Soins de support, Centre Léon Bérard, 28 rue Laënnec,, Lyon, , France

Unité mobile de soutien et de soins palliatifs, Hôpital Saint-Eloi, Montpellier, , France

EMSP, Institut Curie, Paris, , France

EMSP, hôpital Saint aAntoine, Paris, , France

Praz-Coutant, Passy, , France

Unité de Soins Palliatifs, Saint-Etienne, , France

EMSP, Hôpitaux du Léman, Thonon-les-bains, , France

Institut Gustave Roussy, Villejuif, , France

Contact Details

Name: Guillemette Laval, M.D., Ph.D.

Affiliation: University Hospital, Grenoble

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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