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Brief Title: A Study of MIL62 Combined With Orelabrutinib for the Treatment of R/R CD20+B Cell Lymphoma
Official Title: A Phase I/IIa Study on Dose-escalation and Extension of Recombinant Humanized Type II CD20 Monoclonal Antibody MIL62 Injection Combined With BTK Inhibitor Orelabrutinib in the Treatment of Recurrent/Refractory CD20+B-cell Lymphoma
Study ID: NCT04304040
Brief Summary: Dose escalation and expansion phase I/IIa clinical study of recombinant humanized type II CD20 monoclonal antibody MIL62 injection combined with a novel selective Bruton Tyrosine Kinase(BTK) inhibitor Orelabrutinib in the treatment of recurrent/refractory CD20+B cell lymphoma
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
Beijing Hospital, Beijing, Beijing, China
Beijing Shijitan hospital, capital medical university, Beijing, Beijing, China
Cancer hospital, Chinese academy of medical sciences, Beijing, Beijing, China
Affiliated Hospital of Hebei University, Baoding, Hebei, China
Henan Tumor Hospital, Zhengzhou, Henan, China
Hunan Cancer Hospital, Changsha, Hunan, China
First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
The First Hospital of Jilin University, Changchun, Jilin, China
Tianjin People's Hospital, Tianjin, Tianjin, China
Name: Yuankai Shi, PhD
Affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Role: PRINCIPAL_INVESTIGATOR