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Spots Global Cancer Trial Database for Effect of Zinc on Barrett's Metaplasia

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Trial Identification

Brief Title: Effect of Zinc on Barrett's Metaplasia

Official Title: Effect of Zinc on Barrett's Metaplasia

Study ID: NCT01984580

Interventions

zinc gluconate

Study Description

Brief Summary: Using orally administered zinc to patients already diagnosed with the pre-cancerous condition, Barrett's Esophagus, this study is asking two questions: 1. can this zinc administration cause molecular-level changes in the Barrett's tissue? 2. are the changes measured indicative of chemopreventive action by zinc regarding cancer progression?

Detailed Description: 14 days prior to already-scheduled upper endoscopy (EGD) procedures for routine surveillance of Barrett's tissue, patients who have given written, informed consent are randomized (sealed envelope method) and placed on an oral dose of zinc gluconate (26.6 mg zinc BID) or a placebo (molar equivalent of sodium gluconate BID) for 14 days. At the time of endoscopy, 4 biopsies are taken (and pooled) from the Barrett's tissue and 4 from proximal normal esophageal tissue. Biopsies are flash frozen for later analyses by atomic absorption spectroscopy, PAGE and Western immunoblot or RNA microarray.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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