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Spots Global Cancer Trial Database for Longitudinal Oral Microbiome Sampling for BE

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Trial Identification

Brief Title: Longitudinal Oral Microbiome Sampling for BE

Official Title: Repeated Sampling of the Oral Microbiome to Improve Detection of Barrett's Esophagus

Study ID: NCT05133102

Interventions

Sample collection

Study Description

Brief Summary: This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

Detailed Description: Saliva collection is non-invasive and can be performed in clinical and non-clinical settings. As such, saliva testing is a highly attractive method for diagnosing and/or monitoring disease. The investigators previously showed that the bacterial make-up ("microbiome") of saliva is highly distinct in patients with and without Barrett's esophagus (BE), a precursor to esophageal cancer that normally can only be diagnosed by undergoing an upper endoscopy. While the microbiome of saliva is felt to be relatively stable over time, it is unclear whether a microbiome signature for Barrett's esophagus is reproducible within individuals. Also, repeated testing of saliva may improve the ability to diagnose Barrett's esophagus.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

University of Michigan, Ann Arbor, Michigan, United States

Columbia University Irving Medical Center, New York, New York, United States

Contact Details

Name: Julian Abrams, MD

Affiliation: Columbia University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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