Spots Global Cancer Trial Database for Reflectance Confocal Microscopy to Diagnose BCC

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Trial Identification

Brief Title: Reflectance Confocal Microscopy to Diagnose BCC

Official Title: Reflectance Confocal Microscopy to Diagnose Basal Cell Carcinoma

Study ID: NCT03509415

Conditions

Basal Cell Carcinoma

Interventions

In-vivo imaging

Study Description

Brief Summary: It is proposed to undertake a study to determine the diagnostic utility of using RCM for the diagnosis of Basal Cell Carcinoma (BCC) in a tertiary referral centre as outlined by the recent NICE report (Nov 2015). This will allow an assessment of the potential to avoid diagnostic biopsy within the treatment pathway.

Detailed Description: Study Design This is an observational, non-randomised, non-controlled, prospective cohort study to look at the efficacy of in vivo RCM as a diagnostic tool in the diagnosis of BCC. Study Hypothesis The hypothesis of this study is that the use of RCM is would enable a reduction in the number of diagnostic biopsies taken before definitive treatment of BCC by at least 50%. The secondary hypothesis is that the intra- \& inter-observer agreement for interpreting the RCM images will have kappa scores 0.6 or greater (indicating good agreement). Patients will be recruited from the outpatient clinic of Skin Care Network London.