Spots Global Cancer Trial Database for A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas
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Trial Identification
Brief Title: A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas
Official Title: A Randomized, Double-blinded, Regimen-controlled, Phase II, Multicenter Study to Assess the Efficacy and Safety of Two Different Vismodegib Regimens in Patients With Multiple Basal Cell Carcinomas
Study ID: NCT01815840
Conditions
Study Description
Brief Summary: This randomized, double-blind, regimen-controlled, phase II, multicenter study will assess the efficacy and safety of two different vismodegib regimens in participants with multiple basal cell carcinoma. Participants will receive vismodegib 150 mg orally once daily either in an intermittent schedule of 12 weeks vismodegib followed by 8 weeks placebo (Arm A) or as 24 weeks induction followed by an intermittent schedule of 8 weeks placebo followed by 8 weeks vismodegib (Arm B). Anticipated time on study treatment is 72 weeks.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Dermatology Research Associate, Los Angeles, California, United States
Stanford University, Palo Alto, California, United States
Skin Surgery Med Group, Inc, San Diego, California, United States
California Pacific Medical Center Research Institute, Santa Rosa, California, United States
Advanced Derm & Cosmetic Surg, Ormond Beach, Florida, United States
Skin and Cancer Associates and the Center for Cosmetic Enhancement, Plantation, Florida, United States
Emory University Clinic, Atlanta, Georgia, United States
Laser & Skin Surgery Center of Indiana, Carmel, Indiana, United States
Beverly Hospital;Oncology Center Pharmacy, Beverly, Massachusetts, United States
Saint Louis University School of Medicine; Department of Dermatology, Saint Louis, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Long Island Skin Cancer and Dermatologic Surgery, Smithtown, New York, United States
Mariwalla Dermatology, West Islip, New York, United States
The Skin Surgery Center, Winston-Salem, North Carolina, United States
Ohio State University, Columbus, Ohio, United States
Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Dermatology and Laser Center of Charleston PA, Charleston, South Carolina, United States
LKH Innsbruck; Universitätsklinik für Dermatologie, Innsbruck, , Austria
Medizinische Universität Wien; Univ.Klinik für Dermatologie, Wien, , Austria
UBC Department of Dermatology & Skin Sciences, Vancouver, British Columbia, Canada
Dermetics, Burlington, Ontario, Canada
Innovaderm Research Inc., Montreal, Quebec, Canada
CHU Amiens - Hopital Sud, Amiens, , France
Hopital Saint Andre CHU De Bordeaux; Dermatologie, Bordeaux, , France
Chu Site Du Bocage;Dermatologie, Dijon, , France
Hopital Dupuytren; Dermatologie, Limoges, , France
Hopital Timone Adultes; Dermatologie, Marseille, , France
Hopital Saint Eloi; CHU de Montpellier; Svc de Dermatologie, Montpellier, , France
Hopital Hotel Dieu Et Hme; Clinique Dermatologique, Nantes, , France
Hôpital Saint-Louis, Paris, , France
Ch Francois Mitterrand; Medecine Oncologie, Pau, , France
Hopital Nord ; Dermatologie, Saint-Etienne, , France
Universitätsklinik Essen; Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Essen, , Germany
Klinik Johann Wolfgang von Goethe Uni; Klinik für Dermatologie, Venerologie und Allergologie, Frankfurt, , Germany
SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera, , Germany
Medizinische Hochschule Hannover; Klinik für Dermatologie, Allergologie und Venerologie, Hannover, , Germany
UNI-Klinikum Campus Kiel Klinik f.Dermatologie Tagesklinik f.Dermatologie, Kiel, , Germany
Klinikum der LMU München; Klinik und Poliklinik für Dermatologie und Allergologie, München, , Germany
Fachklinik Hornheide; Dermatologie, Münster, , Germany
Universitätsklinikum Tübingen Universitäts-Hautklinik, Tübingen, , Germany
Ospedale San Salvatore (ASL-01); Dip. di Dermatologia U.O.S. di Dermatologia Oncol, L'Aquila, Abruzzo, Italy
Arcispedale Santa Maria Nuova; Dermatologia, Reggio Emilia, Emilia-Romagna, Italy
Università di Brescia; Dipartimento di Dermatologia, Brescia, Lombardia, Italy
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Piemonte, Italy
Ospedale IOT- Palagi Dermatologia 2, Firenze, Toscana, Italy
Hospital General de México, Mexico City, , Mexico
Hospital General Dr. Manuel Gea Gonzalez; Dermatology, Mexico, , Mexico
VU MEDISCH CENTRUM;Afdeling Dermatologie, Amsterdam, , Netherlands
Academ Ziekenhuis Groningen; Medical Oncology, Groningen, , Netherlands
Maastricht University Medical Centre; Dermatologie, Maastricht, , Netherlands
Blokhin Cancer Research Center; General Oncology Department, Moscow, , Russian Federation
FSBI "Russian Oncology Research Center n.a. N. N. Blokhin" of Ministry of Health of the Russian Fed, Moscow, , Russian Federation
City Clinical Oncology Dispensary, Saint-Petersburg, , Russian Federation
Hospital Costa Del Sol; Servicio de Dermatologia, Málaga, Malaga, Spain
Hospital Clinic i Provincial; Servicio de Farmacia, Barcelona, , Spain
Hospital General Universitario de Guadalajara; Servicio de Dermatologia, Guadalajara, , Spain
Hospital General Universitario de Valencia; Servicio de oncologia, Valencia, , Spain
Instituto Valenciano Oncologia; Oncologia Medica, Valencia, , Spain
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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