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Brief Title: The Efficacy and Safety of Using Intralesional 5-fluorouracil for Basal Cell Carcinoma
Official Title: The Efficacy and Safety of Using Intralesional 5-fluorouracil for Basal Cell Carcinoma: Clinical Trail
Study ID: NCT06150144
Brief Summary: The investigators want to assess the safety and efficacy of using intralesional 5-FU for the management of different types of BCC (including all the types EXCEPT the infiltrative one), by estimating different outcomes after the intralesional administration of 5-FU to BCC patient. Patients are randomly selected from the outpatient dermatologic clinic in the Aleppo University Hospital (AUH) over a period of 12 months and then these patients are followed up over another 12 months.
Detailed Description: Brief Description: The investigatorswant to assess the safety and efficacy of using intralesional 5-FU for the management of different types of BCC (including all the types EXCEPT the infiltrative one), by estimating different outcomes after the intralesional administration of 5-FU to BCC patient. Patients are randomly selected from the outpatient dermatologic clinic in the Aleppo University Hospital (AUH) over a period of 12 months and then these patients are followed up over another 12 months. Detailed Description: Clinicians routinely consider surgical removal as the best and sometimes the only cost-effective treatment of Basal cell carcinoma, but several studies have discussed other promising treatment approaches for BCC including 5% 5-FU cream which is indicated for the treatment of superficial BCC, in addition many studies have investigated the efficacy of the combination of 5-FU with Imiquimode or cryoablation presenting promising results, however when searching the medical literature there was only few studies dealing with types other than superficial BCC, in addition intralesional administration of 5-FU alone was not thoroughly assessed so far even though there are some studies showing positive results suggesting 5-FU to be a cost-effective alternative to surgical excision, but as these papers are asking for further studies and stronger evidence the invistigators decided to conduct this study in accordance with the best recommendations reached by latest medical literature.
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Ibrahim Arnaout, Aleppo, , Syrian Arab Republic
Name: Noura Abdulrahman, M.D.
Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
Role: PRINCIPAL_INVESTIGATOR
Name: Rama Haj mharram, M.D.
Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
Role: STUDY_DIRECTOR
Name: Ahmad Yamen Arnaout, M.D.
Affiliation: Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Role: STUDY_DIRECTOR
Name: Silva Ishkhanian, PhD
Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
Role: STUDY_DIRECTOR