Spots Global Cancer Trial Database for Prospective Observational Study to Predict the Response of Biliary Tract Tumors to Immunotherapy

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Trial Identification

Brief Title: Prospective Observational Study to Predict the Response of Biliary Tract Tumors to Immunotherapy

Official Title: Prospective Observational Study on Prediction of Response to First-line Immunotherapy in Patients With Biliary Tract Tumors

Study ID: NCT06048289

Conditions

Biliary Tract Tumor

Cholangiocarcinoma

Interventions

Blood samples, tumor biopsy specimens will be collected

Study Description

Brief Summary: A prospective, observational study to explore multidimensional biomarkers for predicting the efficacy of immunotherapy In biliary tract tumors

Detailed Description: Patient with unresectable advanced or metastatic biliary tract tumors will be enrolled and plan to receive PD-1/PD-L1 inhibitors combined with chemotherapy as first-line treatment. To explore the biomarkers, tumor tissues, acquired from puncture biopsies at baseline, will be collected and investigated by genomic panel sequencing , transcriptome sequencing, and mIHC. Meanwhile, baseline peripheral blood and feces were also collected for detection of plasma proteins, genomes, and metagenomes. Finally, the investigators will analysis and explore predictive biomarkers of immunotherapy in biliary tract tumors.