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Spots Global Cancer Trial Database for A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

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Trial Identification

Brief Title: A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

Official Title: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Darolutamide Plus Androgen Deprivation Therapy (ADT) Compared With Placebo Plus ADT in Patients With High-risk Biochemical Recurrence (BCR) of Prostate Cancer

Study ID: NCT05794906

Study Description

Brief Summary: Researchers are looking for a better way to treat men at high-risk of biochemical recurrence (BCR) of prostate cancer. BCR means that in men who had prostate cancer and were treated by either surgery and/ or radiation therapy, the blood level of a specific protein called PSA rises. PSA is a marker of prostate cancer cells activity. The PSA increase means that the cancer has come back even though conventional imaging such as computed tomography (CT) scans, magnetic resonance imaging (MRI) and bone scans does not show any lesion of prostate cancer. Recently a more sensitive imaging method called prostate-specific membrane antigen \[PSMA\] positron emission tomography \[PET\]) /computed tomography \[CT\]) scan may identify prostate cancer lesions not detectable by conventional imaging. Men with BCR have a higher risk of their cancer spreading to other parts of the body, particularly when PSA levels raised to a certain limit within a short period of time after local therapies. Once the cancer spreads to other parts of the body, it can become even harder to treat. In men with prostate cancer, male sex hormones (also called androgens) like testosterone can help the cancer grow and spread. To reduce androgens levels in these patients, there are treatments that block androgens production in the body called androgen deprivation therapy (ADT). ADT is often used to stop prostate cancer. Another way to stop prostate cancer growth and spread is to block the action of androgen receptors on prostate cancer cells called androgen receptor inhibitors (ARIs). The new generation ARIs including darolutamide can block the action of androgens receptors and are available for the treatment of prostate cancer in addition to ADT. It is already known that men with prostate cancer benefit from these treatments. The main objective of this study is to learn if the combination of darolutamide and ADT prolongs the time that the participants live without their cancer getting worse, or to death due to any cause, compared to placebo (which is a treatment that looks like a medicine but does not have any medicine in it) and ADT given for a pre-specified duration of 24 months. To do this, the study team will measure the time from the date of treatment allocation to the finding of new cancer spread in the participants by using PSMA PET/CT, or death due to any cause. The PSMA PET/CT scans is performed using a radioactive substance called a "tracer" that specifically binds to the prostate-specific membrane antigen (PSMA) which is a protein often found in large amounts on prostate cancer cells. To avoid bias in treatment, the study participants will be randomly (by chance) allocated to one of two treatment groups. Based on the allocated treatment group, the participants will either take darolutamide plus ADT or placebo plus ADT twice daily as tablets by mouth. The study will consist of a test (screening) phase, a treatment phase and a follow-up phase. The treatment duration is pre-specified to be 24 months unless the cancer gets worse, the participants have medical problems, or they leave the study for any reason. In addition, image guided radiotherapy (IGRT) or surgery is allowed and your doctor will explain the benefits and risks of this type of therapy. During the study, the study team will: * take blood and urine samples. * measure PSA and testosterone levels in the blood samples * do physical examinations * check the participants' overall health * examine heart health using electrocardiogram (ECG) * check vital signs * check cancer status using PSMA PET/CT scans, CT, MRI and bone scans * take tumor samples (if required) * ask the participants if they have medical problems About 30 days after the participants have taken their last treatment, the study doctors and their team will check the participants' health and if their cancer worsened. The study team will continue to check this and regularly ask the participants questions about medical problems and subsequent therapies until they leave the study for any reason or until they leave the study for any reason or until the end of the study, whatever comes first.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Mayo Clinic Hospital, Phoenix, Arizona, United States

Arizona Institute of Urology, Tucson, Arizona, United States

City of Hope National Medical Center, Duarte, California, United States

University of Southern California, Los Angeles, California, United States

Tower Urology, Inc, Los Angeles, California, United States

University of California, Los Angeles, Los Angeles, California, United States

University of California Irvine Medical Center, Orange, California, United States

UCSF Med Center Helen Diller Family Comp Cancer Center, San Francisco, California, United States

Colorado Urology (Colorado Clinical Research), Lakewood, Colorado, United States

Clermont Oncology Center, Clermont, Florida, United States

University of Florida - Jacksonville, Jacksonville, Florida, United States

Mid Florida Cancer Centers, Orange City, Florida, United States

Northwestern University Feinberg School of Medicine - Department of Urology, Chicago, Illinois, United States

Jesse Brown VA Medical Center, Chicago, Illinois, United States

Comprehensive Cancer Center, Chicago, Illinois, United States

Urology of Indiana, LLC, Greenwood, Indiana, United States

First Urology PSC, Jeffersonville, Indiana, United States

University of Kansas, Kansas City, Kansas, United States

Chesapeake Urology Associates, Baltimore, Maryland, United States

Johns Hopkins Univ School Med|Sidney Kimmel Comp Cancer Cntr, Baltimore, Maryland, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

UMass Memorial Medical Center - University Campus, Worcester, Massachusetts, United States

Barbara Ann Karmanos Cancer Institute - Detroit, Detroit, Michigan, United States

Michigan Institute of Urology, PC, Troy, Michigan, United States

University of Minnesota Medical Center, Minneapolis, Minnesota, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Urology Cancer Center, PC, Omaha, Nebraska, United States

New Jersey Urology (NJU), Saddle Brook, New Jersey, United States

New Jersey Urology, LLC, Voorhees, New Jersey, United States

NYU Langone Health, New York, New York, United States

Associated Medical Professionals of NY, PLLC, Syracuse, New York, United States

White Plains Hospital, White Plains, New York, United States

Alliance Urology, Greensboro, North Carolina, United States

Wake Forest Baptist Health, Winston-Salem, North Carolina, United States

The Urology Group, Cincinnati, Ohio, United States

Ohio State University Wexner Medical Center, Columbus, Ohio, United States

MidLantic Urology - Bala Cynwyd, Bala-Cynwyd, Pennsylvania, United States

Urological Associates of Lancaster, Lancaster, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

University of Pittsburgh, Pittsburgh, Pennsylvania, United States

VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States

Bon Secours St. Francis Hospital, Greenville, South Carolina, United States

Carolina Urological Research Center, Myrtle Beach, South Carolina, United States

Urology Austin, PLLC (an affiliate of Urology America), Austin, Texas, United States

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Urology San Antonio, PA dba USA Clinical Trials, San Antonio, Texas, United States

The Urology Place, San Antonio, Texas, United States

Spokane Urology PS, Spokane, Washington, United States

Blacktown Hospital, Blacktownn, New South Wales, Australia

Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department, Liverpool, New South Wales, Australia

Macquarie University Hospital, Macquarie University, New South Wales, Australia

GenesisCare Newcastle, Newcastle, New South Wales, Australia

Port Macquarie Base Hospital, Port Macquarie, New South Wales, Australia

St Vincents Hospital Sydney, Sydney, New South Wales, Australia

Sydney Adventist Hospital, Wahroonga, New South Wales, Australia

Westmead Hospital, Westmead, New South Wales, Australia

Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia

Bundaberg Hospital, Genesis Cancer Care - Bundaberg, Bundaberg, Queensland, Australia

Wide Bay Hospital and Health Service - Hervey Bay Hospital, Pialba, Queensland, Australia

Tasman Health Care, Southport, Queensland, Australia

Royal Adelaide Hospital, Adelaide, South Australia, Australia

Eastern Clinical Research Unit - Box Hill, Box Hill, Victoria, Australia

Epworth HealthCare, East Melbourne, Victoria, Australia

Cabrini Medical Centre, Malvern, Victoria, Australia

Royal Melbourne Hospital, Melbourne, Victoria, Australia

Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

Northern Hospital, Epping, , Australia

Barwon Health, Geelong, , Australia

Austin Health, Heidelberg, , Australia

Western Urology, Maribyrnong, , Australia

Prince of Wales Hospital NSW, Randwick, , Australia

Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich, Austria

Krankenhaus der Barmherzigen BrĂŒder, Vienna, Wien, Austria

Medizinische Universitaet Graz - Klinische Abteilung fĂŒr Onkologie - Innere Medizin, Graz, , Austria

Medizinische UniversitÀt Innsbruck, Innsbruck, , Austria

Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, , Austria

Medizinische UniversitĂ€t Wien UniversitĂ€tsklinik f. Innere Medizin I Klinische Abteilung fĂŒr Onkologie, Wien, , Austria

Institut Jules Bordet/Jules Bordet Instituut, Bruxelles, , Belgium

AZ Maria Middelares - Oncology, Gent, , Belgium

UZ Gent - department Urology, Gent, , Belgium

Jessa ziekenhuis - department Oncology, Hasselt, , Belgium

AZ Groeninge Campus Kennedylaan - Urology, Kortrijk, , Belgium

UZ Leuven - department Uro-oncology, Leuven, , Belgium

AssistĂȘncia Multidisciplinar em Oncologia (AMO), Salvador, Bahia, Brazil

Liga Paranaense de Combate ao Cancer-Hosp Erasto Gaertner, Curitiba, Parana, Brazil

Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa ClĂ­nica, Natal, Rio Grande Do Norte, Brazil

Hospital Moinhos de Vento-Centro ClĂ­nico, Porto Alegre, Rio Grande Do Sul, Brazil

Faculdade de Medicina do ABC, Santo André, Sao Paulo, Brazil

Instituto do Cancer do Estado de Sao Paulo, SĂŁo Paulo, Sao Paulo, Brazil

Inst. de AssistĂȘncia MĂ©dica ao SĂ©rvidor PĂșblico Estadual, SĂŁo Paulo, Sao Paulo, Brazil

Hospital Israelita Albert Einstein | Morumbi - Clinical Research Department, SĂŁo Paulo, Sao Paulo, Brazil

Hospital Sirio Libanes, Sao Paulo, , Brazil

Prostate Cancer Centre, Calgary, Alberta, Canada

Vancouver Prostate Centre, Vancouver, British Columbia, Canada

BCCA-Vancouver Island Centre, Victoria, British Columbia, Canada

Nova Scotia Health Authority, Halifax, Nova Scotia, Canada

St. Joseph's Healthcare - Hamilton, Hamilton, Ontario, Canada

London Regional Cancer Program, London, Ontario, Canada

Princess Margaret Cancer Centre - UHN, Toronto, Ontario, Canada

Hopital Hotel-Dieu de Levis, Levis, Quebec, Canada

Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada

BC Cancer - Abbotsford Centre, Abbotsford, , Canada

Centre Hospitalier Universitaire de Sherbrooke (CHUS) - Hopital Fleurimont, Sherbrooke, , Canada

Zhongnan hospital ,Wuhan University, Wuhan, Hubei, China

Hunan Cancer Hospital, Changsha, Hunan, China

Affiliated Hospital of Inner Mongolia Medical University, Hohehot, Inner Mongolia, China

Nanjing First Hospital, Nanjing, Jiangsu, China

Fudan University Shanghai Cancer Center, Shanghai, Jiangsu, China

West China Hospital,Sichuan University, Chengdu, Sichuan, China

The 1st Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China

Peking Union Medical College Hospital (PUMCH) - East Location, Beijing, , China

Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University, Nanjing, , China

Ruijin Hosp. Shanghai Jiaotong Univ.School of Medicine, Shanghai, , China

Tianjin Cancer Hospital, Airport Hospital, Tianjin, , China

Fakultni nemocnice u Sv. Anny, Onkologicko-chirurgicke oddeleni, Brno, , Czechia

Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP), Brno, , Czechia

Multiscan s.r.o., Department: Ambulance klinické onkologie Nemocnice Horovice, Horovice, , Czechia

Fakultni Nemocnice Olomouc (FNOL) - Onkologicka Klinika, Olomouc, , Czechia

Vseobecna fakultni nemocnice - Urologicka klinika, Praha, Praha 2, , Czechia

Aalborg University Hospital, Aalborg, , Denmark

Aarhus Universitetshospital, Aarhus N, , Denmark

Rigshospitalet, Copenhagen, , Denmark

Docrates Klinikka, Helsinki, , Finland

HUS, Meilahden sairaala, Helsinki, , Finland

Oulun yliopistollinen sairaala, Oulu, , Finland

Tampereen yliopistollinen sairaala, keskussairaala, Tampere, , Finland

Turun yliopistollinen keskussairaala, Turku, , Finland

Centre d'oncologie du Pays Basque, Bayonne, , France

HĂŽpital Pellegrin - Bordeaux, Bordeaux, , France

Centre Jean Perrin, Clermont-ferrand, , France

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopitaux Universitaires Henri Mondor (Hopital Henri-Mondor), Creteil, , France

Centre Georges Francois Leclerc Dijon, Dijon, , France

CHU GRENOBLE - Hopital Michallon, Grenoble, , France

HĂŽpital Claude Huriez - Lille, Lille, , France

HĂŽpital de la Timone - Marseille, Marseille, , France

Clinique Clementville, Montpellier, , France

Institut Curie - Ulm - Paris, PARIS cedex 5, , France

Hopital Bichat - Paris, Paris, , France

Centre Hospitalier Lyon Sud, Pierre Benite, , France

Institut de Cancérologie Jean Godinot, Reims, , France

HĂŽpital Pontchaillou, Rennes Cedex, , France

Institue Curie - Saint-Cloud, Saint-cloud, , France

Institut de Cancérologie de l'Ouest - Saint Herblain, Saint-Herblain, , France

ICANS - Institut de Cancérologie de Strasbourg Europe, Strasbourg, , France

HĂŽpital Bretonneau, Tours, , France

Institut de Cancérologie de Lorraine - Alexis Vautrin, Vandoeuvre-les-Nancy, , France

Institut Gustave Roussy - DĂ©partement de MĂ©decine Oncologique, Villejuif Cedex, , France

Klinikum Mannheim GmbH, Mannheim, Baden-WĂŒrttemberg, Germany

Studienpraxis Urologie, NĂŒrtingen, Baden-WĂŒrttemberg, Germany

Klinikum rechts der Isar, MĂŒnchen, Bayern, Germany

Klinikum der UniversitĂ€t WĂŒrzburg, WĂŒrzburg, Bayern, Germany

UniversitÀtsklinikum der Johann Wolfgang Goethe UniversitÀt, Frankfurt, Hessen, Germany

StÀdtisches Klinikum Braunschweig gGmbH, Braunschweig, Niedersachsen, Germany

UniversitÀtsmedizin der Georg-August-UniversitÀt Göttingen, Göttingen, Niedersachsen, Germany

Marienhospital Herne UniversitÀtsklinik, Herne, Nordrhein-Westfalen, Germany

UniversitÀtsklinikum Köln, Köln, Nordrhein-Westfalen, Germany

UniversitĂ€tsklinikum MĂŒnster (UKM), MĂŒnster, Nordrhein-Westfalen, Germany

Medizinische FakultÀt der Otto-von-Guericke UniversitÀt, Magdeburg, Sachsen-Anhalt, Germany

UniversitÀtsklinikum Carl Gustav Carus Dresden, Dresden, Sachsen, Germany

Marien-Krankenhaus Bergisch Gladbach, Bergisch Gladbach, , Germany

Vivantes Klinikum Am Urban, Berlin, , Germany

Charité Campus Benjamin Franklin (CBF), Berlin, , Germany

Martini-Klinik Hamburg, Hamburg, , Germany

UniversitĂ€tsklinikum Jena - Institut fĂŒr Diagnostische und Interventionelle Radiologie, Kinderradiologie, Jena, , Germany

Johannes Gutenberg-UniversitÀt Mainz - Urologie, Mainz, , Germany

Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet, Budapest, , Hungary

Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Urologiai Klinika, Budapest, , Hungary

Orszagos Onkologiai Intezet, Budapest, , Hungary

Budapesti Uzsoki Utcai Korhaz, Budapest, , Hungary

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, , Hungary

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz, Nyiregyhaza, , Hungary

Rambam Health Corporation, Haifa, , Israel

Hadassah Hebrew University Hospital Ein Kerem, Jerusalem, , Israel

Shaare Zedek Medical Center, Jerusalem, , Israel

Clalit Health Services Rabin Medical Center-Beilinson Campus, Petah Tikva, , Israel

Sheba Medical Center, Tel Hashomer, , Israel

Sourasky Medical Center, Tel-Aviv, , Israel

Istituto Nazionale Tumori IRCCS Fondazione G.Pascale, Napoli, Campania, Italy

A.O.U. di Bologna Policlinico S.Orsola Malpighi, Bologna, Emilia-Romagna, Italy

AUSL di Bologna, Bologna, Emilia-Romagna, Italy

A.O.U. di Modena - Policlinico, Modena, Emilia-Romagna, Italy

AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Emilia-Romagna, Italy

IRCCS Centro di Riferimento Oncologico (CRO), Pordenone, Friuli-Venezia Giulia, Italy

Fondazione PTV Policlinico Tor Vergata, Roma, Lazio, Italy

IRCCS Istituti Fisioterapici Ospitalieri - IFO, Roma, Lazio, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio, Italy

ASST Papa Giovanni XXIII, Bergamo, Lombardia, Italy

Istituto Clinico Humanitas - Humanitas Mirasole S.p.A., Milano, Lombardia, Italy

Ospedale San Raffaele s.r.l., Milano, Lombardia, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy

Molinette Hospital University of Torino, Torino, Piemonte, Italy

A.O.U. Consorziale Policlinico, Bari, Puglia, Italy

A.O.U. Ospedali Riuniti Foggia, Foggia, Puglia, Italy

Istituto Oncologico Veneto IRCCS (IOV), Padova, Veneto, Italy

IRCCS Ospedale Sacro Cuore Don Calabria, Verona, Veneto, Italy

A.O.U.I. Verona, Verona, Veneto, Italy

IRCCS Ist Nazionale Tumori GE - Oncologia Medica, Genova, , Italy

A.O. di Perugia - Ospedale Santa Maria della Misericordia - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Perugia, , Italy

Santa Chiara Hospital, Trento, , Italy

Hokkaido University Hospital, Sapporo, Hokkaido, Japan

Kanazawa University Hospital, Kanazawa, Ishikawa, Japan

Yokohama City University Hospital, Yokohama, Kanagawa, Japan

Osaka University Hospital, Suita, Osaka, Japan

Tokyo Medical and Dental University Hospital, Bunkyo-ku, Tokyo, Japan

Kagoshima University Hospital, Kagoshima, , Japan

Kyoto University Hospital, Kyoto, , Japan

Albert Schweitzer Ziekenhuis - Dordwijk, Dordrecht, , Netherlands

Catharina Ziekenhuis, Eindhoven, , Netherlands

Universitair Medisch Centrum Groningen, Groningen, , Netherlands

Tergooiziekenhuizen Hilversum, Hilversum, , Netherlands

St. Antonius Ziekenhuis, Nieuwegein, , Netherlands

St. Franciscus Gasthuis, Rotterdam, , Netherlands

HagaZiekenhuis van Den Haag, The Hague, , Netherlands

Auckland City Hosptial, Auckland, , New Zealand

Canterbury Urology Research Trust, Christchurch, , New Zealand

Tauranga Urology Research Limited, Tauranga, , New Zealand

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, , Poland

Swietokrzyskie Centrum Onkologii, Kielce, , Poland

Centrum Medyczne iMed24, Krakow, , Poland

Medrise Sp. z o.o. Centrum Badan Klinicznych, Lublin, , Poland

Szpital Grochowski im. dr.med. Rafala Masztaka, Warszawa, , Poland

EMC Instytut Medyczny SA, Wroclaw, , Poland

Centro Clinico Academico Braga | Braga, Portugal, Braga, , Portugal

Centro Hospitalar e Universitario de Coimbra EPE (CHUC), Coimbra, , Portugal

Hospital CUF Tejo, Lisboa, , Portugal

Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica, Lisboa, , Portugal

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica, Lisboa, , Portugal

Centro Hospitalar UniversitĂĄrio de Lisboa Norte | Heart and Vessels Department, Lisboa, , Portugal

IPO Lisboa, Lisboa, , Portugal

Centro Hospitalar Universitario do Porto, Porto, , Portugal

Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain

Hospital del Mar, Barcelona, , Spain

Hospital ClĂ­nic i Provincial de Barcelona, Barcelona, , Spain

Hospital FundaciĂł Puigvert, Barcelona, , Spain

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, , Spain

Hospital Universitario Puerta del Mar, Cadiz, , Spain

MD Anderson International Espanya, S.A., Madrid, , Spain

Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna, Madrid, , Spain

Centro Integral OncolĂłgico Clara Campal, Madrid, , Spain

H. General Uiversitario Morales Meseguer - Department of Urology, Murcia, , Spain

Hospital Universitario Virgen de la Victoria | Cardiology Department, MĂĄlaga, , Spain

Virgen del Rocio University Hospital - Oncology Department, Sevilla, , Spain

Instituto Valenciano de OncologĂ­a, Valencia, , Spain

Hospital Universitari i PolitĂšcnic La Fe, Valencia, , Spain

Goteborgs Universitet, Gothenburg, , Sweden

Skane University Hospital - Department of Urology, Malmo, , Sweden

Uppsala Universitet - Akademiska Sjukhuset (Uppsala University Hospital), Uppsala, , Sweden

Tungs' Taichung MetroHarbor Hospital, Taichung, , Taiwan

National Taiwan University Hospital, Taipei, , Taiwan

Koo Foundation Sun Yet-Sen Cancer Centre, Taipei, , Taiwan

Chang Gung Memorial Hospital at Linkou, Taoyuan, , Taiwan

Bedford Hospital - Bedfordshire Hospitals NHS Foundation Tru, Bedford, Bedfordshire, United Kingdom

Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom

Royal Surrey County Hospital, Manchester, Surrey, United Kingdom

University College London Hospitals NHS Foundation Trust, London, , United Kingdom

Royal Marsden Hospital (London), London, , United Kingdom

Charing Cross Hospital, London, , United Kingdom

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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