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Spots Global Cancer Trial Database for Bladder Cancer and Neoadjuvant Chemotherapy Efficiency Before Cystectomy

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Trial Identification

Brief Title: Bladder Cancer and Neoadjuvant Chemotherapy Efficiency Before Cystectomy

Official Title: Survival prEdiction in bLadder Cancer Patients Treated by nEoadjuvant Chemotherapy Before cysTectomy

Study ID: NCT06294054

Study Description

Brief Summary: This study will allow the investigators to better assess the efficiency of neoadjuvant chemotherapy before cystectomy by training a predictive model on different patient cohorts with bladder cancer.

Detailed Description: The project is based on three prospective cohorts of patients with MIBC: the VESPER trial (n=296), the St-Louis Hospital cohort (n=99), and the COBLAnCE cohort (n=312). Using WES and RNAseq, the investigators will determine genomic instability, DDR gene mutation and molecular subtypes. After digitization of tumour slides, the investigators will train and test predictive models based on deep learning approaches to predict outcome after neoadjuvant chemotherapy, either by estimating molecular subtypes and genetic features from pathological images, or by directly defining a prognostic signature. The statistical analyses will assess the performance of the models combining genomic instability, DNA Damage Response mutations and/or molecular subtyping to predict outcome after neoadjuvant chemotherapy and compare them with the models based on WSI deep learning approaches. These results will help to design new therapeutic strategies.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Centre de lutte contre le cancer François Baclesse, Caen, , France

Centre de recherche des Cordeliers, Paris, , France

Hôpital Saint-Louis AP-HP, Paris, , France

Institut Curie Centre de Recherche, Paris, , France

Institut Curie, Paris, , France

Institut Gustave Roussy, Paris, , France

Mines ParisTech, Paris, , France

Contact Details

Name: Yves ALLORY, MD

Affiliation: Institut Curie

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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