Spots Global Cancer Trial Database for MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy

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Trial Identification

Brief Title: MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy

Official Title: Randomized Controlled Trial With a MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy - MOSAIC

Study ID: NCT04391790

Conditions

Bladder Cancer

Interventions

Cystectomy and modified urinary conduit

Cystectomy and standard urinary conduit ad modum Bricker

Study Description

Brief Summary: Cystectomy is the chosen treatment of bladder cancer in 400 cases every year in DK. In replacement of the removed bladder, a urinary diversion is constructed using 15cm of terminal ilium (Ad Modum Bricker). Ureteral strictures are diagnosed in 15% of the cystectomized patients, and these patients are at increased risk of infections, loss of renal function and repeated interventions. The left ureter is diagnosed with 70% of all strictures, presumably due to the construction of the urinary diversion. A modified urinary diversion have been tested in two small studies. The modified diversion is prolonged with 5cm compared to the conventional urinary diversion. The prolongation permits the urinary diversion to reach both the left and the right side of the abdomen, resulting in greater resection of non-viably distal ureter and less mobilization of the left ureter, lowering the rates of strictures.

Detailed Description: