Spots Global Cancer Trial Database for Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer
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Trial Identification
Brief Title: Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer
Official Title: A Phase II Protocol for Patients With Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent With Radiosensitizing Chemotherapy Following a Thorough Transurethral Surgical Re-Staging
Study ID: NCT00981656
Conditions
Study Description
Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin, mitomycin C, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with cisplatin may kill more tumor cells. PURPOSE: This phase II trial is studying how well radiation therapy given together with chemotherapy works in treating patients with stage I bladder cancer.
Detailed Description: After completion of study treatment, patients are followed up every 3 months for 1 year, every 4 months for 1 year, every 6 months for 3 years, and annually thereafter until termination of the study.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Emory Crawford Long Hospital, Atlanta, Georgia, United States
Winship Cancer Institute of Emory University, Atlanta, Georgia, United States
St. Agnes Hospital Cancer Center, Baltimore, Maryland, United States
Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River, Massachusetts, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Beth Israel Medical Center - Petrie Division, New York, New York, United States
Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio, United States
Barberton Citizens Hospital, Barberton, Ohio, United States
Cancer Care Center, Incorporated, Salem, Ohio, United States
Cancer Treatment Center, Wooster, Ohio, United States
Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania, United States
University of Texas Medical Branch, Galveston, Texas, United States
Norris Cotton Cancer Center - North, Saint Johnsbury, Vermont, United States
Contact Details
Name: William U. Shipley, MD, FACR
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR
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