Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Adenoma

Urinary Bladder Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

This group will be prescribed a Dietary Intervention that reduces energy intake by 500-1000 kcal/day and induces a weight loss of approximately 1-2 pounds per week during the intervention, with the weight loss goal individualized to each participant.

This group will be prescribed a Dietary Intervention that reduces energy intake by 500-1000 kcal/day and induces a weight loss of approximately 1-2 pounds per week during the intervention, with the weight loss goal individualized to each participant. In addition, this group will be prescribed moderate-intensity Physical Activity Intervention that will progressively increase to the goal of 250 minutes/week.

The behavioral weight loss intervention strategies will not be limited to, self-monitoring, goal setting, problem solving, mastery skills, social support, and relapse prevention. Participants will receive a standard behavioral weight control program, delivered on a one-on-one basis. They will attend in-person sessions (\~30-45 minutes) with time to: distribute intervention materials, interact with the participant, identify participants that need additional support, and conduct the intervention. Each in-person visit focuses on a specific behavioral topic related to weight loss to address eating behaviors. Subjects will also participate in phone calls with the interventionist (\~10 minutes). Depending on the week, subjects will have between 10 and 45 minutes of total intervention contact.

Dietary Intervention

The behavioral weight loss intervention strategies will not be limited to, self-monitoring, goal setting, problem solving, mastery skills, social support, and relapse prevention. Participants will receive a standard behavioral weight control program, delivered on a one-on-one basis. They will attend in-person sessions (\~30-45 minutes) with time to: distribute intervention materials, interact with the participant, identify participants that need additional support, and conduct the intervention. Each in-person visit focuses on a specific behavioral topic related to weight loss to address physical activity behaviors. Subjects will also participate in phone calls with the interventionist (\~10 minutes). Depending on the week, subjects will have 10 to 45 minutes of total intervention contact.

Physical Activity Intervention

Dana Bovbjerg, PhD

John Jakicic, PhD

The goal of the research is to provide a first critical test of the novel scientific idea that a combined diet and exercise intervention may ameliorate shortening of leukocyte telomere length (LTL) in individuals with histories of successfully treated non-metastatic bladder cancer (BC) or colorectal adenoma (CRA) compared to a diet only intervention.

Lifestyle Change for Better Health

Leukocyte Telomere Length: Diet and Exercise Trial

BMI will be calculated from height and weight measurements

Body composition will be measured by dual-energy x-ray absorptiometry (DXA)

Regional adiposity will be measured by dual-energy x-ray absorptiometry (DXA)

Waist-to-hip ratio will be calculated from waist and hip measurements

Physical Activity will be objectively measured with SenseWear BodyMedia

The Paffenbarger Physical Activity Questionnaire will be used to obtain a self-reported measure of physical activity

Cardiorespiratory Fitness (oxygen consumption) will be measured by submaximal treadmill test

The Center for Epidemiologic Studies Depression Scale will be used to obtain a self-reported measure of depressive symptoms

The State subscale of the State Trait Anxiety Inventory will be used to obtain a self-reported measure of acute anxiety

The Perceived Stress Scale will be used to obtain a self-reported measure of perceived stress

The Pittsburgh Sleep Quality Index will be used to obtain a self-reported measure of overall sleep quality

The Functional Assessment of Cancer Therapy - Bladder Cancer will be used to obtain a self-reported measure of health-related quality of life

LTL will be measured in blood samples from participants

Telomerase will be measured in blood samples from participants

8-OHdG will be measured in samples from participants

SOD1 will be measured in samples from participants

SOD2 will be measured in samples from participants

Gpx will be measured in samples from participants

SIR will be measured in samples from participants

Spots Global Cancer Trial Database for Lifestyle Change for Better Health

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