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Brief Title: Urine VOC Investigation in Bladder Cancer Diagnosis
Official Title: Investigation of Urine Volatile Organic Compounds as Novel Diagnostic Biomarker in Bladder Cancer
Study ID: NCT05671289
Brief Summary: The goal of this study to investigate the volatile organic compounds (VOCs) in the urine samples of both healthy individual and bladder cancer patients, using gas chromatography - mass spectrometry. Researchers aim to find a set of certain VOCs specific to bladder cancer and use this set to construct a diagnostic model that can help diagnosing bladder cancer. Participants will be asked to collect their early morning midstream urine in a predesignated container. Researchers will compare urine VOCs from bladder cancer patients and healthy individuals to see if there is any VOC whose concentration differ significantly among the two groups.
Detailed Description: Specifically, participants will be asked to collect 35-45 ml of their early morning midstream urine sample in a predesignated polytetrafluoroethylene bottle. Researcher will collect participants' health information, including their: 1)smoking history; 2)comorbidity; 3) history of past urological procedure; 4)medication; 5)pathology diagnosis after surgery, if participants have bladder cancer.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
First Affiliated Hospital of Xian Jiaotong University, Xi'an, Shaanxi, China
Name: Jinhai Fan, MD
Affiliation: First affiliated hospital of Xian jiaotong university
Role: STUDY_DIRECTOR