Spots Global Cancer Trial Database for A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer
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Trial Identification
Brief Title: A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer
Official Title: A Phase II, Single Arm, Single Agent, Multicentre, Adaptive 2-Stage Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of AZD4877 Administered Weekly in Patients With Recurrent Advanced Urothelial Cancer
Study ID: NCT00661609
Interventions
Study Description
Brief Summary: The purpose of this Phase II study is to determine if AZD4877, an experimental drug that is a novel anti-mitotic agent (Eg5 or Kinesin Spindle Protein inhibitor that interferes with tumor cell division leading to tumor growth), can reduce tumor sizes in patients with bladder cancer
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Palo Alto, California, United States
Research Site, San Bernardino, California, United States
Research Site, Southington, Connecticut, United States
Research Site, Miami, Florida, United States
Research Site, Atlanta, Georgia, United States
Research Site, Marietta, Georgia, United States
Research Site, Chicago, Illinois, United States
Research Site, Scarborough, Maine, United States
Research Site, Ann Arbor, Michigan, United States
Research Site, Minneapolis, Minnesota, United States
Research Site, Hackensack, New Jersey, United States
Research Site, Morristown, New Jersey, United States
Research Site, New York, New York, United States
Research Site, Charlotte, North Carolina, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Woonsocket, Rhode Island, United States
Research Site, Seattle, Washington, United States
Research Site, Morgantown, West Virginia, United States
Research Site, Vancouver, British Columbia, Canada
Research Site, Halifax, Nova Scotia, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Quebec, , Canada
Research Site, Berlin, , Germany
Research Site, Dresden, , Germany
Research Site, Dusseldorf, , Germany
Research Site, Munchen, , Germany
Research Site, Munster, , Germany
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Leeds, West Yorkshire, United Kingdom
Research Site, Glasgow, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Southampton, , United Kingdom
Research Site, Surrey, , United Kingdom
Contact Details
Name: Gary Hudes, MD
Affiliation: Fox Chase Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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