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Spots Global Cancer Trial Database for MRI in Clinical Staging and Estimation of Treatment Response in Bladder Cancer

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Trial Identification

Brief Title: MRI in Clinical Staging and Estimation of Treatment Response in Bladder Cancer

Official Title: Magnetic Resonance Imaging of Bladder Cancer

Study ID: NCT02662166

Conditions

Bladder Cancer

Interventions

MR imaging

Study Description

Brief Summary: Bladder cancer (BC) as the most common malignancy arising from the urinary tract continues to be a major health problem. This prospective non-randomized study will enroll 150 patients undergoing magnetic resonance imaging (MRI) at different stages of their diagnostic and therapeutical process. The enrolled patients with suspected BC (BC) based on cystoscopy will have their initial MRI examination before transurethral resection of bladder tumor (TUR-BT) and biomarker collection. After pathology review of the histological specimens, patients will be treated according to standard clinical practice. The second MRI examination will be performed before therapeutic intervention, if TUR-BT alone is not sufficient enough. Neoadjuvant chemotherapy will be applied in high risk patients having muscle invasison, while intermediate risk patient - T1 high grade or carcinoma in situ patients - will be treated using Bacillus Calmette-Guerin (BCG) instilliations. After the completion of the neoadjuvant chemotherapy or BCG treatment, the patients will undergo the third MRI examination. Low risk patients will be followed by annual with MRI examination.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Department of Urology, Central Hospital of Pori, Pori, , Finland

University of Turku, Turku, , Finland

Contact Details

Name: Peter Boström, MD, PhD

Affiliation: Department of Urology, University of Turku and Turku University Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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