Spots Global Cancer Trial Database for Influence of Opioids on Circulating Tumor Cells in Radical Cystectomy
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Trial Identification
Brief Title: Influence of Opioids on Circulating Tumor Cells in Radical Cystectomy
Official Title: Influence of Peri-operative Opioids on Circulating Tumor Cells in Patients Undergoing Robot-Assisted Laparoscopic Radical Cystectomy
Study ID: NCT04358718
Conditions
Study Description
Brief Summary: Multiple lines of evidence have shown that perioperative opioids requirement was associated with poor outcomes in cancer patients, including increased cancer progression and metastases and reduced survival in patients with lung, breast, prostate, and bladder cancer. Circulating tumor cells (CTCs) have been validated as prognostic biomarkers of a number of cancers. The aim of this study is to investigate the effects of perioperative opioids on the number of CTCs in patients receiving robot-assisted laparoscopic radical cystectomy. The difference of the amounts of perioperative opioids is achieved by using general anesthesia combined with intravenous opioid-based analgesia intra- and post-operatively in one group and general analgesia combined with epidural ropivacaine-based analgesia in the other group.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Renji hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China
Contact Details
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