Spots Global Cancer Trial Database for Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery

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Trial Identification

Brief Title: Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery

Official Title: Рrospective Multicenter Randomized 3 Phase Study Evaluating the Role of Prolonged Antibiotic Prophylaxis as a Measure to Reduce the Incidence of Postoperative Complications After Radical Cystectomy With ERAS Protocol

Study ID: NCT05392634

Conditions

Bladder Cancer

Interventions

Meropenem 1000 mg

Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg

Study Description

Brief Summary: The current usage of antibiotic prophylaxis (AP) in radical cystectomy (RC) is aimed to reducing the incidence of surgical site infections and incidence of unnecessary prescribing of antibiotics. There are a huge number of different AP protocols according to Urological Associations. However, there is no convincing evidence to support variations and duration of AP which requires a randomized clinical trial on AP when performing variants of RC with uroderivation. Research hypothesis: The use of prolonged antibiotic prophylaxis (5 days), depending on the glomerular filtration rate, does not affect the incidence of postoperative complications.

Detailed Description: