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Spots Global Cancer Trial Database for Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC

Official Title: Neoadjuvant Immune-Modulating Radiation With Durvalumab (MEDI4736) Prior to Radical Cystectomy in Patients With Muscle-Invasive Bladder Carcinoma (RADIANT)

Study ID: NCT04543110

Conditions

Bladder Cancer

Study Description

Brief Summary: This study assesses the effect of sequential radiation and durvalumab immunotherapy given as treatment prior to surgery with radical cystectomy for bladder cancer.

Detailed Description: In this phase II study, patients who are either not eligible or declined to have chemotherapy prior to surgery for muscle-invasive bladder cancer may consent and enrol to study. Patients will have single 8 Gy hypofractionated radiation to bladder followed by 3 cycles of durvalumab immunotherapy prior to radical cystectomy. This study will assess the safety and tolerability, pathological and radiological response, and immune biological correlatives to understand the effect of radiation and durvalumab.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cross Cancer Institute, Edmonton, Alberta, Canada

Juravinski Cancer Centre, Hamilton, Ontario, Canada

London Health Sciences Centre, London, Ontario, Canada

The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada

Contact Details

Name: Michael Ong, MD

Affiliation: Ottawa Hospital Research Institute

Role: PRINCIPAL_INVESTIGATOR

Name: Naveen Basappa, MD

Affiliation: Cross Cancer Institute

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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