The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Nitrocamptothecin in Treating Patients With Metastatic Cancer of the Urinary Tract
Official Title: Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced/Metastatic Urothelial Tract Tumors
Study ID: NCT00006026
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of nitrocamptothecin in treating patients who have metastatic cancer of the urinary tract.
Detailed Description: OBJECTIVES: I. Determine the objective response to nitrocamptothecin in patients with metastatic urothelial tract tumors. II. Determine the response rate in these patients when treated with this regimen. III. Determine the duration of objective response in these patients when treated with this regimen. IV. Characterize the toxicities of this treatment in this patient population. OUTLINE: This is a multicenter study. Patients receive oral nitrocamptothecin daily on days 1-5. Treatment continues weekly every 3 weeks for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 6 weeks until disease progression. PROJECTED ACCRUAL: A total of 14-25 patients will be accrued for this study.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
U.Z. Gasthuisberg, Leuven, , Belgium
Centre Jean Perrin, Clermont-Ferrand, , France
Centre de Lute Contre le Cancer,Georges-Francois Leclerc, Dijon, , France
CRLCC Nantes - Atlantique, Nantes-Saint Herblain, , France
Centre Henri Becquerel, Rouen, , France
Rambam Medical Center, Haifa, , Israel
Azienda Ospedaliera di Padova, Padova (Padua), , Italy
Rotterdam Cancer Institute, Rotterdam, , Netherlands
Hospital Universitario 12 de Octubre, Madrid, , Spain
Ospedale San Giovanni, Bellinzona, , Switzerland
Clinique De Genolier, Genolier, , Switzerland
Name: Pierre Fumoleau, MD, PhD
Affiliation: Centre Georges Francois Leclerc
Role: STUDY_CHAIR