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Spots Global Cancer Trial Database for Microsampling Approach for Monitoring of Kinase Inhibitor Targeted Therapies

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Trial Identification

Brief Title: Microsampling Approach for Monitoring of Kinase Inhibitor Targeted Therapies

Official Title: Development of a Microsampling Approach for Personalized Monitoring of Kinase Inhibitor Targeted Therapies

Study ID: NCT05598788

Study Description

Brief Summary: The MISTIK project aims at clinically validating the technique of oral anticancer drugs determination by volumetric absorptive micro-sampling and at comparing the results to measurements performed on venous samples.

Detailed Description: The International recommendations for the validation of DBS-based methods will be applied (Capiau et al, TDM, 2019) by including 40 patients per molecule of interest. Nine drugs will be monitored : axitinib, olaparib, regorafénib, cabozantinib, niraparib, talazoparib, palbociclib, abemaciclib, tucatinib. Two samples will be collected from each patient, one by venous sampling and the second at the same time (approximately) using a capillary blood sample derived from a finger prick.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Centre Eugène Marquis Unicancer, Rennes, , France

Rennes University Hospital, Rennes, , France

Institut de cancérologie Strasbourg Europe, Strasbourg, , France

Contact Details

Name: VERDIER Marie-Clemence

Affiliation: Rennes University Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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