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Brief Title: A Study of AL2846 Versus Zoledronic Acid in Subjects With Advanced Non-Small Cell Lung Cancer With Bone Metastasis
Official Title: A Randomized, Double-blind and Imitation, Parallel-control, Multicenter Phase II Study of AL2846 Versus Zoledronic Acid in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) With Bone Metastasis
Study ID: NCT04325776
Brief Summary: AL2846 is a multi-target tyrosine kinase receptor inhibitor with obvious selective to c-met, suggesting that its anti-tumor effect mainly inhibits the activation of key downstream oncogenic pathways by inhibiting expression of c-met, tumor angiogenesis and tumor cell migration.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Anhui Chest Hospital, Hefei, Anhui, China
Henan Cancer Hospital, Zhengzhou, Henan, China
China-Japan Union Hospital Of Jilin University, Changchun, Jilin, China
Jinzhou Central Hospital, Jinzhou, Liaoning, China
Shenyang Chest Hospital, Shenyang, Liaoning, China
Sir Run Run Shaw Hospital (SRRSH), Hangzhou, Zhejiang, China
The First Hospital of Jiaxing, Jiaxing, Zhejiang, China
Quzhou People's Hospital, Quzhou, Zhejiang, China