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Spots Global Cancer Trial Database for Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute

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Trial Identification

Brief Title: Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute

Official Title: A National, Prospective, Randomized, Multicenter, Controlled Head-to-Head Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute in Filling of Contained Bone Defects

Study ID: NCT00841152

Conditions

Bone Neoplasm

Study Description

Brief Summary: This study is designed to perform a head-to-head comparison of two synthetic ceramic bone graft substitutes, bioactive glass (BAG) and beta-tricalcium phosphate (TCP), in filling of contained bone defects following surgical evacuation of benign bone tumor or tumor-like conditions. Based on the investigators' previous preclinical research and an ongoing single-center randomized clinical trial on bioactive glass filling, the investigators expect BAG filling to be more efficient compared to TCP in promotion of defect healing and functional recovery after surgery.

Detailed Description: This study is designed to perform a head-to-head comparison of two synthetic ceramic bone graft substitutes, bioactive glass (BAG) and beta-tricalcium phosphate (TCP), in filling of contained bone defects following surgical evacuation of benign bone tumor or tumor-like conditions. Small metacarpal and phalangeal enchondromas (Stratum I) and large long-bone lesions (Stratum II) will be evaluated separately. Aside with the head-to-head comparison of the two synthetic bone graft substitutes, autologous bone graft (Stratum I) and allogeneic bone graft (Stratum II) will be used as the standard of care controls.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Helsinki University Hospital, Helsinki, , Finland

Kuopio University Hospital, Kuopio, , Finland

Oulu University Hospital, Oulu, , Finland

Tampere University Hsopital, Tampere, , Finland

Turku University Central Hospital, Turku, , Finland

Contact Details

Name: Hannu T Aro, MD, PhD

Affiliation: Turku University Central Hospital and University of Turku

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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