Spots Global Cancer Trial Database for Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury

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Trial Identification

Brief Title: Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury

Official Title: Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury in Patients With Head and Neck Cancer

Study ID: NCT05303259

Conditions

Brain Injuries

Interventions

Bevacizumab

Study Description

Brief Summary: To investigate the effect of Bevacizumab on asymptomatic radiotherapy-induced brain injury patients with head and neck cancer.

Detailed Description: Radiotherapy-induced brain injury (RI) is a serious complication of radiotherapy in head and neck cancer (HNC) patients. Previous studies have confirmed that Bevacizumab has a good effect on patients with symptomatic RI .However, patients with RI maybe do not show clinical symptoms in the early stage. The clinical symptoms will appear with the progression of the RI lesion. There has been no relevant research on whether early intervention is necessary for asymptomatic RI. The investigators conduct this multicenter, randomized clinical research to explore the efficacy and safety of Bevacizumab in asymptomatic RI.