⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for 131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: 131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors

Official Title: A Prospective Non-randomized Study of 131I-L19SIP Radioimmunotherapy (RIT) in Combination With Whole Brain Radiation Therapy (WBRT) in Patients With Multiple Brain Metastases From Solid Tumors

Study ID: NCT01125085

Study Description

Brief Summary: The aim of this Proof of Concept study is to determine the therapeutic potential of the L19SIP antibody, labeled with the radionuclide 131I in combination with external beam radiation, for the treatment of patients with multiple brain metastases following the promising results with this agent in previous clinical studies. The L19SIP antibody is a fully human antibody, capable of preferential localization around tumor blood vessels while sparing normal tissues. The formation of new blood vessels is a rare event in the adult (exception made for the female reproductive cycle), but is a pathological feature in most aggressive types of cancer. The presented study follows a Phase I and a subsequent Phase I/II dose finding and efficacy study with the same agent in patients with a variety of cancers where 131I-L19SIP had shown an excellent tolerability and therapeutic benefit for some patients enrolled in the study.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Irccs Centro Di Riferimento Oncologico (Cro) - Aviano, Aviano, , Italy

Ospedali Riuniti Di Bergamo, Bergamo, , Italy

Azienda Ospedaliero UNIVERSITARIA CAREGGI DI FIRENZE, Firenze, , Italy

ASUR Zona Territoriale 9, Medicina Nucleare Ospedale di Macerata, Macerata, , Italy

Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale Di Napoli, Napoli, , Italy

Arcispedale Santa Maria Nuova Di Reggio Emilia, Reggio Emilia, , Italy

Irccs Istituto Clinico Humanitas, Rozzano (mi), , Italy

Irccs Ospedale Casa Sollievo Della Sofferenza - San Giovanni Rotondo, San Giovanni Rotondo (FG), , Italy

Barts and the London NHS Trust Hospital, London, , United Kingdom

UCLH, Department of Cancer Medicine, London, London, , United Kingdom

Contact Details

Name: Secondo Lastoria, Dr

Affiliation: ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI FONDAZIONE GIOVANNI PASCALE DI NAPOLI

Role: PRINCIPAL_INVESTIGATOR

Name: Paul Mullholand, Dr

Affiliation: UCLH, Department of Cancer Medicine, London (UK)

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: