Spots Global Cancer Trial Database for MRI Characterization of Mammographically Detected DCIS

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Trial Identification

Brief Title: MRI Characterization of Mammographically Detected DCIS

Official Title: MRI Characterization of Mammographically Detected Calcifications and Ductal Carcinoma in Situ

Study ID: NCT03495011

Conditions

Breast Cancer, Stage 0

Interventions

Breast MRI

Laboratory Biomarker Analysis

Study Description

Brief Summary: This is a single institution, prospective observational clinical trial for women with mammographically identified calcifications that may represent ductal carcinoma in situ (DCIS). The purpose of this study is to determine whether quantitative, multiparametric breast MRI performed prior to surgical resection can biologically characterize this common pre-invasive malignancy, ductal carcinoma in situ (DCIS), which typically presents in asymptomatic women as suspicious calcifications on mammography.

Detailed Description: The investigators will assess whether MRI signatures can determine which calcifications identified prior to surgical resection actually harbor DCIS, and whether these imaging features correlate with pathologic markers of proliferation (Ki-67) and inflammation (cox-2) within DCIS lesions. The investigators will also explore whether quantitative MRI features in the peri-tumoral region correlate with prognostic microenvironment markers of inflammation (TNFα) and angiogenesis (VEGF). Finally, investigators will assess whether a multivariate model using these markers can accurately predict risk of recurrence based on a multi-gene assay (Oncotype DX DCIS score).