Spots Global Cancer Trial Database for Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?

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Trial Identification

Brief Title: Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?

Official Title: Variation of the Neutrophil To Lymphocyte Ratio During Opioid-Free General Anesthesia Associated With Thoracic Wall Blocks Vs General Anesthesia, in Breast Cancer Quadrantectomy: a Randomized Controlled Trial

Study ID: NCT04172220

Conditions

Breast Cancer Female

Interventions

Midazolam

PECS

Opioid-free general anesthesia

General anesthesia

Postoperative analgesia

Study Description

Brief Summary: The Neutrophil to Lymphocyte Ratio (NLR) is a frequently used biomarker of the systemic inflammatory response and is considered one of the most sensitive markers of inflammation. Many studies have documented the association between the use of opioid drugs in the acute phase -as it can be considered the use during general anesthesia- and the increase of the NLR value. Such increase could determine a temporary phase of immunodepression in the immediate post operative period with consequent increase of the inflammatory state. This study intends to assess whether different anesthetic techniques can be associated with different variations of the intra-patient NLR value between pre- and post-surgery. Patient will be randomized to receive either local regional anesthesia protocols with thoracic wall blocks (PEC I and serratus plane block) associated with opioid-free general anesthesia (PECS + Opioid-free GA) or general anesthesia.

Detailed Description: