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Brief Title: Reirradiation With Concurrent Paclitaxel for Breast Cancer
Official Title: A Phase I Study of Twice Weekly Paclitaxel and Radical Re-irradiation Using Helical Tomotherapy for Aggressive Chest Wall Recurrences of Breast Cancer
Study ID: NCT02058667
Brief Summary: The purpose of this trial in addition to a dose finding study for concurrent Paclitaxel, will be to establish a treatment algorithm for chest wall reirradiation. A nominal margin of at least 5cm will be used on the protocol and extending it to 7cm. Considering the standard treatment of breast cancer incorporates a cumulative dose of 60Gy, delivering an additional 50.4 Gy followed by a boost should target a total dose of 120 Gy.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Markey Cancer Center, Lexington, Kentucky, United States
Name: Jonathan M Feddock, MD
Affiliation: UK Markey Cancer Center
Role: PRINCIPAL_INVESTIGATOR