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Brief Title: A Study of Ruxolitinib in Combination With Capecitabine in Subjects With Advanced or Metastatic HER2-negative Breast Cancer
Official Title: A Randomized, Double-Blind, Phase 2 Study of Ruxolitinib or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic HER2-Negative Breast Cancer
Study ID: NCT02120417
Brief Summary: This was a randomized, double-blind, placebo-controlled phase 2 clinical trial comparing the overall survival of women with advanced or metastatic HER2-negative breast cancer who received treatment with capecitabine in combination with ruxolitinib versus those who received treatment with capecitabine alone.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
, Birmingham, Alabama, United States
, Chandler, Arizona, United States
, Sedona, Arizona, United States
, La Jolla, California, United States
, Los Angeles, California, United States
, Oxnard, California, United States
, San Diego, California, United States
, San Francisco, California, United States
, Santa Monica, California, United States
, Aurora, Colorado, United States
, Denver, Colorado, United States
, New Haven, Connecticut, United States
, Washington, District of Columbia, United States
, Fort Myers, Florida, United States
, Hialeah, Florida, United States
, Miami, Florida, United States
, Plantation, Florida, United States
, Saint Petersburg, Florida, United States
, Tampa, Florida, United States
, Atlanta, Georgia, United States
, Marietta, Georgia, United States
, Savannah, Georgia, United States
, Chicago, Illinois, United States
, Quincy, Illinois, United States
, Springfield, Illinois, United States
, Urbana, Illinois, United States
, Ames, Iowa, United States
, Wichita, Kansas, United States
, Louisville, Kentucky, United States
, Baton Rouge, Louisiana, United States
, Baltimore, Maryland, United States
, Detroit, Michigan, United States
, Kalamazoo, Michigan, United States
, Duluth, Minnesota, United States
, Minneapolis, Minnesota, United States
, Kansas City, Missouri, United States
, Saint Louis, Missouri, United States
, Grand Island, Nebraska, United States
, Omaha, Nebraska, United States
, Camden, New Jersey, United States
, Hackensack, New Jersey, United States
, Farmington, New Mexico, United States
, Albany, New York, United States
, Bronx, New York, United States
, Johnson City, New York, United States
, New York, New York, United States
, Goldsboro, North Carolina, United States
, Pinehurst, North Carolina, United States
, Canton, Ohio, United States
, Cincinnati, Ohio, United States
, Cleveland, Ohio, United States
, Columbus, Ohio, United States
, Middletown, Ohio, United States
, Portland, Oregon, United States
, Bethlehem, Pennsylvania, United States
, Philadelphia, Pennsylvania, United States
, Pittsburgh, Pennsylvania, United States
, Charleston, South Carolina, United States
, Greenville, South Carolina, United States
, Chattanooga, Tennessee, United States
, Germantown, Tennessee, United States
, Nashville, Tennessee, United States
, Arlington, Texas, United States
, Bedford, Texas, United States
, Dallas, Texas, United States
, El Paso, Texas, United States
, Fort Worth, Texas, United States
, Houston, Texas, United States
, McAllen, Texas, United States
, Plano, Texas, United States
, Tyler, Texas, United States
, Ogden, Utah, United States
, Salt Lake City, Utah, United States
, Fairfax, Virginia, United States
, Norfolk, Virginia, United States
, Richmond, Virginia, United States
, Salem, Virginia, United States
, Seattle, Washington, United States
, Green Bay, Wisconsin, United States
, Milwaukee, Wisconsin, United States
, La Roche Sur Yon, , France
, Paris Cedex 10, , France
, Paris, , France
, Alba, , Italy
, Fano, , Italy
, Foggia, , Italy
, Lecco, , Italy
, Milano, , Italy
, Naples, , Italy
, Pontedera, , Italy
, Roma, , Italy
, Saronno, , Italy
, Lisbon, , Portugal
, A Coruña, , Spain
, Barcelona, , Spain
, Jaén, , Spain
, Lleida, , Spain
, Madrid, , Spain
, Cardiff, , United Kingdom
, Glasgow, , United Kingdom
, Kingston Upon Thames, , United Kingdom
, London, , United Kingdom
, Nottingham, , United Kingdom
, Sutton, , United Kingdom
, Taunton, , United Kingdom
, Truro, , United Kingdom
, Yeovil, , United Kingdom
Name: Gerard Kennealey, MD
Affiliation: Incyte Corporation
Role: STUDY_DIRECTOR