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Brief Title: A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Who Have Received Prior Anti-HER2 And Chemotherapy-based Treatment
Official Title: A Two-Cohort, Open-Label, Multicenter Study of Trastuzumab Emtansine (T-DM1) in HER2-Positive Locally Advanced or Metastatic Breast Cancer Patients Who Have Received Prior Anti-HER2 and Chemotherapy-Based Treatment
Study ID: NCT01702571
Brief Summary: This two-cohort, open-label, multicenter study will assess the safety, efficacy and tolerability of trastuzumab emtansine in participants with HER2-positive locally advanced breast cancer (LABC) or metastatic breast cancer (mBC) who have received prior anti-HER2 and chemotherapy-based treatment. Participants in Cohort 1 will be drawn from the general participant population; Cohort 2 will include only Asian participants.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CEMIC, Buenos Aires, , Argentina
Centro Oncologico Riojano Integral (CORI), La Rioja, , Argentina
Hospital Privado De Comunidad; General Practice, Mar Del Plata, , Argentina
Mater Hospital; Patricia Ritchie Centre for Cancer Care and Research, North Sydney, New South Wales, Australia
Calvary Mater Newcastle; Medical Oncology, Waratah, New South Wales, Australia
Westmead Hospital; Medical Oncology and Pallative Care, Westmead, New South Wales, Australia
Haematology & Oncology Clinics of Australia Research Centre, South Brisbane, Queensland, Australia
Ashford Cancer Center Research, Kurralta Park, South Australia, Australia
Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, Australia
Sunshine Hospital; Oncology Research, St Albans, Victoria, Australia
Fiona Stanley Hospital, Murdoch, Western Australia, Australia
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg, , Austria
Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie, Wien, , Austria
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie, Wien, , Austria
Institut Jules Bordet, Anderlecht, , Belgium
UZ Brussel, Brussel, , Belgium
Cliniques Universitaires St-Luc, Bruxelles, , Belgium
GHdC Site Notre Dame, Charleroi, , Belgium
UZ Antwerpen, Edegem, , Belgium
UZ Gent, Gent, , Belgium
UZ Leuven Gasthuisberg, Leuven, , Belgium
CHU Sart-Tilman, Liège, , Belgium
Clinique Ste-Elisabeth, Namur, , Belgium
Sint Augustinus Wilrijk, Apotheek, Wilrijk, , Belgium
*X*Instituto Nacional do Cancer - INCA, Rio de Janeiro, RJ, Brazil
Hospital Sao Lucas - PUCRS, Porto Alegre, RS, Brazil
Centro de Pesquisas Oncologicas - CEPON, Florianopolis, SC, Brazil
Hospital Sirio Libanes; Centro de Oncologia, Sao Paulo, SP, Brazil
Hospital Sao Jose, Sao Paulo, SP, Brazil
MHAT Serdika; Department of medical oncology, Sofia, , Bulgaria
SHATO - Sofia, Sofia, , Bulgaria
SHATOD - Sofia, Sofia, , Bulgaria
District Oncology Dispensary Wit Stationary, Varna, , Bulgaria
BC Cancer - Surrey, Surrey, British Columbia, Canada
British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver, British Columbia, Canada
Dr. H. Bliss Murphy Cancer Centre; Oncology, St. John's, Newfoundland and Labrador, Canada
Royal Victoria Regional Health Centre; c/o Oncology Clinical Trials, Barrie, Ontario, Canada
London Regional Cancer Centre, London, Ontario, Canada
Southlake Regional Health Center; Community Care Clinic / Oncology, Newmarket, Ontario, Canada
St. Michael'S Hospital, Toronto, Ontario, Canada
Hopital Maisonneuve- Rosemont; Oncology, Montreal, Quebec, Canada
Mcgill University - Royal Victoria Hospital; Oncology, Montreal, Quebec, Canada
Cancer Hospital Chinese Academy of Medical Sciences., Beijing, , China
Beijing Cancer Hospital, Beijing, , China
Chinese PLA General Hospital, Beijing, , China
Sun Yat-sen Memorial Hospital, Guangzhou, , China
Sun Yet-sen University Cancer Center, Guangzhou, , China
Harbin Medical University Cancer Hospital, Harbin, , China
Jiangsu Cancer Hospital, Nanjing City, , China
Fudan University Shanghai Cancer Center, Shanghai City, , China
Tianjin Cancer Hospital, Tianjin, , China
Zhejiang Cancer Hospital, Zhejiang, , China
Clinical Hospital Centre Zagreb, Zagreb, , Croatia
Aalborg Universitetshospital, Klinik Kirurgi-Kræft, Onkologisk afd., Aalborg, , Denmark
Herlev Hospital; Afdeling for Kræftbehandling, Herlev, , Denmark
Nordsjællands Hospital, Hillerød, Onkologisk Afdeling, Hillerod, , Denmark
Rigshospitalet; Onkologisk Klinik, København Ø, , Denmark
Odense Universitetshospital, Onkologisk Afdeling R, Odense C, , Denmark
Sygehus Syd Roskilde; Onkologisk/haematologisk ambulatorium, Roskilde, , Denmark
Vejle Sygehus; Onkologisk Afdeling, Vejle, , Denmark
Hospital Metropolitano de Santiago, Santiago, , Dominican Republic
Clinica Alcivar, torre 1;Private office, Guayaquil, , Ecuador
Hospital Solca Portoviejo; Oncologia, Portoviejo, , Ecuador
North Estonia Medical Centre Foundation; Oncology Center, Tallinn, , Estonia
Helsingin yliopistollinen keskussairaala, Helsinki, , Finland
KYS Sadesairaala; Syopatautien poliklinikka, Kuopio, , Finland
Tampere University Hospital; Dept of Oncology, Tampere, , Finland
Turku Uni Central Hospital; Oncology Clinics, Turku, , Finland
Clinique De L Europe; Radiotherapie Chimiotherapie, Amiens, , France
ICO Paul Papin; Oncologie Medicale., Angers, , France
Institut Sainte Catherine, Avignon, , France
Hopital Jean Minjoz - CHU de Besançon, Besançon, , France
Clinique Tivoli; Chimiotherapie Radiotherapie, Bordeaux, , France
Institut Bergonie; Oncologie, Bordeaux, , France
Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie, Bordeaux, , France
Cli De La Porte De Saint Cloud; Hop De Jour De Chimiotherapie, Boulogne-billancourt, , France
Hopital Morvan; Oncologie - Radiotherapie, Brest, , France
Centre Francois Baclesse; Radiotherapie, Caen, , France
Centre Jean Perrin; Oncologie, Clermont Ferrand, , France
Centre Georges Francois Leclerc; Oncologie 3, Dijon, , France
Chu Grenoble - Hopital Albert Michallon; Departement de Cancero-Hematologie, Grenoble, , France
Centre Hartmann, Levallois Perret, , France
Centre Oscar Lambret; Senologie, Lille, , France
Clinique Chenieux; Oncology, Limoges, , France
Ch Bretagne Sud Site Scorff; Oncologie Medicale, Lorient, , France
Centre Leon Berard, Lyon, , France
Institut Paoli Calmettes; Oncologie Medicale, Marseille, , France
Hopital Layne; Medecine Ambulatoire, Mont-de-marsan, , France
Centre Val Aurelle Paul Lamarque; Recherche Clinique, Montpellier, , France
Centre Antoine Lacassagne; Hopital De Jour A2, Nice, , France
Institut Curie; Oncologie Medicale, Paris, , France
HOPITAL TENON; Cancerologie Medicale, Paris, , France
Polyclinique Francheville; Med Chimiotherapie Radiotherapie, Perigueux, , France
Centre Catalan D' Oncologie, Perpignan, , France
Clinique Armoricaine Radiologie; Hopital de Jour, Plerin, , France
Pole Regional De Cancerologie, Poitiers, , France
Institut Jean Godinot; Oncologie Medicale, Reims CEDEX, , France
Polyclinique De Courlancy; Centre Radiotherapie Oncologie, Reims, , France
Centre Eugene Marquis; Unite Huguenin, Rennes, , France
Centre Henri Becquerel; Oncologie Medicale, Rouen, , France
Ico Rene Gauducheau; Oncologie, Saint Herblain, , France
Centre Rene Huguenin; CONSULT SPECIALISEES, St Cloud, , France
Centre Paul Strauss; Oncologie Medicale, Strasbourg, , France
Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse, , France
Clinique Pasteur; Oncologie Medicale, Toulouse, , France
Centre Henry S Kaplan - CHU Bretonneau ; service oncologie, Tours, , France
Centre Alexis Vautrin; Oncologie Medicale, Vandoeuvre-les-nancy, , France
Institut Gustave Roussy; Pathologie Mammaire, Villejuif, , France
Hämatologisch-onkologische Praxis Dr. med. - Heinrich, - Bangerter, Augsburg, , Germany
Praxis Dres. Schilling & Till, Berlin, , Germany
Schwerpunktpraxis Onkologie/Hämatologie Dr. Dirk Pott, Dr. Christian Tirier und Carla Verena u.w., Bottrop, , Germany
Onkozentrum Dres. Göhler, Dresden, , Germany
Dres. Joerg Weniger, Annette Bittrich und Berit Schuetze, Erfurt, , Germany
Universitätsklinikum Erlangen; Frauenklinik, Erlangen, , Germany
OncoResearch Lerchenfeld GmbH, Hamburg, , Germany
HOPA MVZ GmbH, Hamburg, , Germany
Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie, Hannover, , Germany
Institut für Versorgungsforschung in der Onkologie GbR Koblenz, Koblenz, , Germany
Klinikum Leverkusen; Med. Klinik III / Onkologie, Leverkusen, , Germany
Klinikum der Universität München; Campus Großhadern; Klinik und Poliklinik für Frauenheilkunde, Muenchen, , Germany
Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe, Münster, , Germany
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe, Offenbach, , Germany
Praxis für Hämatologie und Onkologie, Porta Westfalica, , Germany
Universitaetsfrauenklinik; Und Poliklinik Am Klinikum, Rostock, , Germany
Universitätsklinik Tübingen; Frauenklinik, Tübingen, , Germany
HELIOS Dr. Horst Schmidt Kliniken Wiesbaden; Klinik für Gynäkologie und gynäkologische Onkologie, Wiesbaden, , Germany
Hämatologisch-Onkologische Schwerpunktpraxis Dres. Schlag & Schöttker, Würzburg, , Germany
University General Hospital of Heraklion, Crete, , Greece
Uni Hospital of Ioannina; Oncology Dept., Ioannina, , Greece
University Hospital of Patras Medical Oncology, Patras, , Greece
Papageorgiou General Hospital; Medical Oncology, Thessaloniki, , Greece
Centro Oncológico Sixtino / Centro Oncológico SA, Guatemala, , Guatemala
Princess Margaret Hospital; Oncology, Hong Kong, , Hong Kong
Prince of Wales Hosp; Dept. Of Clinical Onc, Shatin, , Hong Kong
Ogyi, Orszagos Gyogyszereszeti Intezet, Budapest, , Hungary
Szent Imre Hospital; Dept. of Oncology, Budapest, , Hungary
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly, Budapest, , Hungary
Magyar Honvedseg Egeszsegugyi Kozpont; Fázis I-es Klinikai Farmakológiai Vizsgálóhely, Budapest, , Hungary
Kaposi Mor County Hospital; Dept. of Oncology, Kaposvar, , Hungary
Landspitali University Hospital, Department of Medical Oncology, Reykjavik, , Iceland
Cipto Mangunkusumo General Hospital; Hematology & Oncology, Jakarta, , Indonesia
Dharmais National Cancer Center, Jakarta, , Indonesia
MRCCC Siloam Semanggi Hospital, Jakarta, , Indonesia
Cork Uni Hospital; Oncology Dept, Cork, , Ireland
St Vincent'S Uni Hospital; Medical Oncology, Dublin, , Ireland
Mater Misericordiae Uni Hospital; Oncology, Dublin, , Ireland
University Hospital Limerick - Oncology, Limerick, , Ireland
Azienda Ospedaliera San Giuseppe Moscati, Avellino, Campania, Italy
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania, Italy
Università degli Studi Federico II; Clinica di Oncologia Medica, Napoli, Campania, Italy
Ospedale Bellaria; U.O. Oncologia Medica, Bologna, Emilia-Romagna, Italy
A.O.U. Policlinico di Modena, Modena, Emilia-Romagna, Italy
Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia, Piacenza, Emilia-Romagna, Italy
RCCS - Centro di Riferimento; Oncologia Medica B, Aviano (PN), Friuli-Venezia Giulia, Italy
Divisione Onc Med dell'Azienda, Udine, Friuli-Venezia Giulia, Italy
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche, Roma, Lazio, Italy
Ospedale S.S. Trinità Nuovo; Divisione Oncologia, Sora, Lazio, Italy
IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A, Genova, Liguria, Italy
ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit, Cremona, Lombardia, Italy
ASST DI LECCO; Oncologia Medica, Lecco, Lombardia, Italy
Ospedale San Raffaele; Medical Oncology, Milano, Lombardia, Italy
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1, Milano, Lombardia, Italy
Istituto Europeo Di Oncologia, Milano, Lombardia, Italy
Fondazione Salvatore Maugeri; Divisione Di Oncologia Medica, Pavia, Lombardia, Italy
Casa di Cura Multimedica S.p.A.; Dipartimento Oncologico, Sesto San Giovanni (MI), Lombardia, Italy
Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico, Candiolo, Piemonte, Italy
Ospedale Maggiore Della Carita; Oncologia Medica, Novara, Piemonte, Italy
A.O. Città della Salute e della Scienza - Presidio Molinette; divisione oncologia medica, Torino, Piemonte, Italy
Ospedale Antonio Perrino; Oncologia Medica, Brindisi, Puglia, Italy
Ospedale Vito Fazzi; Div. Oncoematologia, Lecce, Puglia, Italy
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima; Oncologia Medica, Catania, Sicilia, Italy
A.O.U Careggi, Florence, Toscana, Italy
Azienda usl 5 Di Pisa-Ospedale Di Pontedera;U.O. Oncologia, Pontedera, Toscana, Italy
Ospedale Misericordia E Dolce; Oncologia Medica, Prato, Toscana, Italy
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica, Perugia, Umbria, Italy
Ospedale Civile; Oncologia Medica, Camposampiero, Veneto, Italy
Ospedale Busonera; Oncologia Medica, Padova, Veneto, Italy
A.O.U.I. VERONA-OSPEDALE BORGO TRENTO; ONCOLODIA MEDICA-d.O., Verona, Veneto, Italy
Kyungpook National University Medical Center, Daegu, , Korea, Republic of
Gachon Medical School Gil Medical Center; Medical Oncology, Incheon, , Korea, Republic of
Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology, Seoul, , Korea, Republic of
Yonsei University Severance Hospital; Medical Oncology, Seoul, , Korea, Republic of
Korea University Anam Hospital; Oncology Haemotology, Seoul, , Korea, Republic of
CHL Hopital Municipal; Oncology, Luxembourg, , Luxembourg
Hospital General de México, Mexico City, Mexico CITY (federal District), Mexico
Medica Sur Centro Oncologico Integral, D.f., , Mexico
Hospital Hmg Coyoacan, DF, , Mexico
CENTRO MÉDICO NACIONAL SIGLO XXI; Hospital de Especialidades Oncología, Mexico City, , Mexico
Inst. Nacional de Cancerologia; Investigacion Clinica, Mexico City, , Mexico
Instituto Nacional de Ciencias Médicas Y de La Nutricion Zubirán, Mexico City, , Mexico
Antoni Van Leeuwenhoek Ziekenhuis; Inwendige Geneeskunde, Amsterdam, , Netherlands
Amphia Ziekenhuis, Breda, , Netherlands
MC Haaglanden; Oncologie, Den Haag, , Netherlands
Deventer Ziekenhuis; Interne Geneeskunde, Deventer, , Netherlands
Ziekenhuisgroep Twente, Hengelo, Hengelo, , Netherlands
Spaarne Ziekenhuis; Inwendige Geneeskunde, Hoofddorp, , Netherlands
Medisch Centrum Leeuwarden; Interne, Leeuwarden, , Netherlands
Orbis Medisch Centrum; Inwendige Geneeskunde, Sittard-Geleen, , Netherlands
Twee Steden Ziekenhuis - Locatie Tilburg; Interne Geneesekunde, Tilburg, , Netherlands
Oslo Universitetssykehus HF; Ullevål sykehus, Oslo, , Norway
Centro Hemato Oncologico Panama, Panama, , Panama
Centro Oncologico America, Panama, , Panama
Instituto;Oncologico Miraflores, Lima, , Peru
Clinica de Especialidades Medicas, Lima, , Peru
Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej, Bialystok, , Poland
Szpital Specjalistyczny POO im. ks. B.Markiewicza; Dzienny Oddz Chemioter i Hematologii Onkol, Brzozów, , Poland
Świętokrzyskie Centrum Onkologii; Dział Chemioterapii, Kielce, , Poland
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii, Kraków, , Poland
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii, Otwock, , Poland
Wojewódzki Szpital Specjalistyczny Nr 3, Rybnik, , Poland
IPO de Lisboa; Servico de Oncologia Medica, Lisboa, , Portugal
Hospital da Luz; Departamento de Oncologia Medica, Lisboa, , Portugal
IPO do Porto; Servico de Oncologia Medica, Porto, , Portugal
Narodny Onkologicky Ustav; Oddelenie klinickej onkologie A, Bratislava, , Slovakia
Fakultna nemocnica Trencín; Onkologicke odd., Trencin, , Slovakia
Institute of Oncology Ljubljana, Ljubljana, , Slovenia
Hospital General Universitario de Elche; Servicio de Oncologia, Elche, Alicante, Spain
Hospital General de Elda; Servicio de Oncologia, Elda, Alicante, Spain
Hospital Univ. Central de Asturias; Servicio de Oncologia, Oviedo, Asturias, Spain
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona, Barcelona, Spain
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell, Barcelona, Spain
Hospital de Jerez de la Frontera; Servicio de Oncologia, Jerez de La Frontera, Cadiz, Spain
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba, Cordoba, Spain
Hospital de Donostia; Servicio de Oncologia Medica, San Sebastian, Guipuzcoa, Spain
Hospital Universitario Son Espases, Palma De Mallorca, Islas Baleares, Spain
Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia, Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia, Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital Severo Ochoa; Servicio de Oncologia, Leganes, Madrid, Spain
Hospital Quiron de Madrid; Servicio de Oncologia, Pozuelo de Alarcon, Madrid, Spain
Hospital Xeral Cíes; Servicio de Oncologia, Vigo, Pontevedra, Spain
Hospital Universitari Sant Joan de Reus; Servicio de Oncologia, Reus, Tarragona, Spain
Hospital de Cruces; Servicio de Oncologia, Bilbao, Vizcaya, Spain
Hospital General Univ. de Alicante; Servicio de Oncologia, Alicante, , Spain
Hospital del Mar; Servicio de Oncologia, Barcelona, , Spain
Hospital Quiron Barcelona; Servicio de Oncologia, Barcelona, , Spain
Hospital San Pedro De Alcantara; Servicio de Oncologia, Caceres, , Spain
Hospital Universitari de Girona Dr. Josep Trueta; Servicio de Oncologia, Girona, , Spain
Hospital Universitario San Cecilio; Servicio de Oncologia, Granada, , Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia, Jaen, , Spain
Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología, La Coruña, , Spain
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia, Lerida, , Spain
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, , Spain
HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia, Madrid, , Spain
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Malaga, , Spain
Complejo Hospitalario de Pontevedra; Servicio de Oncologia, Pontevedra, , Spain
Instituto Valenciano Oncologia; Oncologia Medica, Valencia, , Spain
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia, , Spain
Hospital General Universitario de Valencia; Servicio de oncologia, Valencia, , Spain
Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza, , Spain
Karolinska Hospital; Oncology - Radiumhemmet, Stockholm, , Sweden
Norrlands universitetssjukhus; Onkologkliniken, Umeå, , Sweden
National Cheng Kung Uni Hospital; Surgery, Tainan, , Taiwan
Chi-Mei Medical Centre; Hematology & Oncology, Tainan, , Taiwan
VETERANS GENERAL HOSPITAL; Department of General Surgery, Taipei, , Taiwan
Department of Surgery, King Chulalongkorn Memorial Hospital, Bangkok, , Thailand
Pramongkutklao Hospital; Medicine - Medical Oncology Unit, Bangkok, , Thailand
Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial, Chiang Mai, , Thailand
Gazi Uni Medical Faculty Hospital; Oncology Dept, Ankara, , Turkey
Gaziantep University Medical Faculty, Medical Oncology Department, Gaziantep, , Turkey
Bezmialem Vakif Univ Medical; Bezmialem Vakif Univ T, Istanbul, , Turkey
Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul, , Turkey
Istanbul Uni of Medicine Faculty; Oncology Dept, Istanbul, , Turkey
Kartal Dr Lutfi Kirdar Sehir Hastanesi; Medical Oncology Department, Istanbul, , Turkey
Marmara Uni Faculty of Medicine; Medical Oncology, Istanbul, , Turkey
Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir, , Turkey
Dokuz Eylul Uni ; Medical Oncology, Izmir, , Turkey
Kocaeli University Faculty of Medicine; Medical oncology, Izmit, , Turkey
Tawam Hospital, Al Ain, , United Arab Emirates
Aberdeen Royal Infirmary, Aberdeen, , United Kingdom
University Hospital Birmingham Queen Elizabeth Hospital, Birmingham, , United Kingdom
Kent & Canterbury Hospital, Canterbury, , United Kingdom
University Hospital coventry; Oncology Department, Coventry, , United Kingdom
Eastborne District General Hospital, Eastbourne, , United Kingdom
Western General Hospital; Clinical Oncology, Edinburgh, , United Kingdom
St Margaret'S Hospital; Breast Unit, Epping, , United Kingdom
Royal Devon & Exeter Hospital; Oncology Centre, Exeter, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Diana Princess of Wales Hosp., Grimsby, , United Kingdom
Huddersfield Royal Infirmary, Huddersfield, , United Kingdom
Castle Hill Hospital; The Queen's Centre for Oncology & Haematology, Hull, , United Kingdom
Ipswich Hospital; Oncology Pharmacy, Ipswich, , United Kingdom
Royal Lancaster Infirmary, Morecambe Bay Hospitals Nhs Trust, Lancaster, , United Kingdom
Royal Free Hospital; Dept of Oncology, London, , United Kingdom
Guys & St Thomas Hospital; Department of Oncology, London, , United Kingdom
St George'S Hospital; Oncology Research Office /Oncology Opd, London, , United Kingdom
Sarah Cannon Research Institute, London, , United Kingdom
Maidstone & Tonbridge Wells Hospital; Kent Oncology Center, Maidstone, , United Kingdom
Christie Hospital; Breast Cancer Research Office, Manchester, , United Kingdom
Mount Vernon Hospital, Middlesex, , United Kingdom
Plymouth Oncology Centre; Clinical Trials Unit, Plymouth, , United Kingdom
Queen Alexandra Hospital, Portsmouth, Portsmouth, , United Kingdom
Queen's Hospital; Oncology, Romford, , United Kingdom
Weston Park Hospital; Cancer Clinical Trials Centre, Sheffield, , United Kingdom
Royal Shrewsbury Hospital, Shrewsbury, , United Kingdom
Singleton Hospital; Pharmacy, Swansea, , United Kingdom
Yeovil District Hospital; Macmillan Cancer Unit, Yeovil, , United Kingdom
York District Hospital, York, , United Kingdom
Unidad de Mastologia y Atencion a la Mujer, Barcelona, , Venezuela
Instituto Oncológico Luis Razetti, Caracas, , Venezuela
Instituto de Oncologia y Hematologia UCV, Caracas, , Venezuela
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR