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Spots Global Cancer Trial Database for Ultra High Field MRI and MRS Techniques in Diagnosing Breast Cancer

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Trial Identification

Brief Title: Ultra High Field MRI and MRS Techniques in Diagnosing Breast Cancer

Official Title: Ultra-High Field (7 Tesla) MRI/MRS Evaluation of Breast Cancer

Study ID: NCT01938651

Conditions

Breast Cancer

Study Description

Brief Summary: This pilot clinical trial studies ultra-high field magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques in diagnosing breast cancer. New diagnostic procedures may be a more sensitive way to detect breast cancer.

Detailed Description: PRIMARY OBJECTIVES: I. To implement quantitative dynamic contrast-enhanced (DCE)-MRI, diffusion-weighted (DW)-MRI, 31 phosphorus (31P) MRS, magnetization transfer (MT)-MRI, chemical exchange saturation transfer (CEST)-MRI, and high-resolution structural imaging at 7 Tesla in patients for diagnosing breast tumors. OUTLINE: Patients undergo measurement of tumor perfusion and permeability using DCE-MRI, tumor cellularity using DW-MRI, phospholipid metabolism using 31P MRS, macromolecular content using MT-MRI, and cellular protein content using CEST-MRI. Diagnostic performance of one, or a combination, of these metrics will be investigated in the context of breast cancer.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Contact Details

Name: Thomas Yankeelov

Affiliation: Vanderbilt-Ingram Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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