Spots Global Cancer Trial Database for Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

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Trial Identification

Brief Title: Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

Official Title: Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

Study ID: NCT01000883

Conditions

Breast Cancer

Interventions

biologic sample preservation procedure

laboratory biomarker analysis

biopsy

Study Description

Brief Summary: RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at tissue and blood samples from women with locally advanced or metastatic breast cancer

Detailed Description: OBJECTIVES: * Collect , catalogue, and store biological specimens from patients with locally advanced or metastatic breast cancer * To collect clinical data from these patients containing identifiers, demographics, epidemiologic review, clinical evaluation, treatment, and long-term follow-up. * To provide an efficient bi-directional flow of clinical information and specimens between laboratory and clinical scientists in order to foster innovative translational research. OUTLINE: This is a multicenter study. Patients undergo core biopsy and blood sampling at diagnosis, between chemotherapy regimens, and prior to definitive surgery. Tumor markers are assessed using immunohistochemistry and flow cytometry. PROJECTED ACCRUAL: A total of 500 patients will be accrued for this study.