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Brief Title: Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Official Title: Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery: A Prospective Cohort Study (Breast CAncer Surgery Postsurgical Pain)
Study ID: NCT03408717
Brief Summary: Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking. The study aims to identify clinically relevant and genetic risk factors for persistent postsurgical pain that can be reliably distinguished statistically.
Detailed Description: The study will focus on: (i) risk factors representing biopsychosocial processes that influence chronic pain, such as pain and psychological vulnerability; (ii) genetic factors relating to mechanistic pathways to persistent pain generation. Patients will be recruited from those undergoing breast cancer surgery at the mentioned site. Pain and anxiety assessment will be conducted via visual analogue scoring, mechanical temporal summation assessment and a series of questionnaires. After the surgery, all patients will be given appropriate analgesia, and the pain score and analgesia usage will be recorded. Phone survey will be conducted 4 and 6 months, respectively, after surgery to determine the outcomes.
Minimum Age: 21 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Duke University Medical Center, Durham, North Carolina, United States
KK Women's and Children's Hospital, Singapore, , Singapore
Name: Ban Leong Sng, FANZCA
Affiliation: KK Women's and Children's Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Ashraf Habib, MBBCh, FRCA
Affiliation: Duke University
Role: PRINCIPAL_INVESTIGATOR