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Spots Global Cancer Trial Database for Autotaxin: a Potential Biomarker for Breast Cancer.

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Trial Identification

Brief Title: Autotaxin: a Potential Biomarker for Breast Cancer.

Official Title: Is Autotaxin a Promising Biomarker for Breast Cancer

Study ID: NCT05680311

Conditions

Breast Cancer

Study Description

Brief Summary: The goal of this clinical trial is to test the efficiency of Autotaxin (ATX) as a biomarker for breast cancer patients. The main questions it aims to answer are; * is ATX a reliable tumor marker for breast cancer patients in diagnosis * can ATX differentiate cancer patients from non-cancer ones

Detailed Description: 80 breast cancer patients and 30 normal patients with no known cancer history were enrolled in this study. All patients were female. The mean ages of cancer patients were 58.2 and 52.7 consecutively for cancer and non-cancer patients. The mean serum ATX levels of cancer and non-cancer patients were 1570.72 and 121.86 ng/mL consecutively (p=0.001). The cut-off value of ATX serum level was 178.49ng/mL according to the ROC analysis. The area under the ROC curve was 0.901showing that ATX is very efficient in distinguishing between two diagnostic groups (diseased/normal). ATX also showed good correlations with known tumor markers (CEA, CA15-3, CA125 levels). ATX levels were still higher than the cut-off value even in cancer patients with normal or low classical tumor marker levels.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

Ankara Etlik City Hospital, Ankara, , Turkey

Contact Details

Name: Duray Seker, Professor

Affiliation: Ankara Etlik City Hospital

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

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