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Spots Global Cancer Trial Database for Physical Activity and Breast Cancer Risk in Postmenopausal Women:the SHAPE Study

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Trial Identification

Brief Title: Physical Activity and Breast Cancer Risk in Postmenopausal Women:the SHAPE Study

Official Title: Physical Activity and Breast Cancer Risk in Postmenopausal Women: the SHAPE Study

Study ID: NCT00359060

Conditions

Breast Cancer

Interventions

Physical activity

Study Description

Brief Summary: Purpose of the SHAPE study is to examine the effects of an 1-year exercise programme on endogenous hormone levels associated with breast cancer among sedentary postmenopausal women and whether a decrease in intra-abdominal fat is associated with a lowering of these hormone levels.

Detailed Description: Physical activity has been associated with a decreased risk for breast cancer. The biological mechanism(s) underlying the association between physical activity and breast cancer is not clear. Most prominent hypothesis is that physical activity may protect against breast cancer through reduced lifetime exposure to endogenous hormones. Another hypothesis is that physical activity prevents overweight and abdominal adiposity. In this intervention study, 189 sedentary postmenopausal women who are aged 50-69 years are randomly allocated to an intervention or a control group. The intervention consists of an 1-year moderate-to-vigorous intensity aerobic and strength training exercise programme. Participants allocated to the control group are requested to retain their habitual exercise pattern. Primary study parameters measured at baseline, at four months and at 12 months are: serum concentrations of endogenous estrogens, endogenous androgens, sex hormone binding globulin and insulin. Other study parameters include: amount of total and abdominal fat, weight, BMI, body fat distribution, physical fitness, blood pressure and lifestyle factors. This study will contribute to the body of evidence relating physical activity and breast cancer risk and will provide insight into possible mechanisms through which physical activity might be associated with reduced risk of breast cancer in postmenopausal women.

Eligibility

Minimum Age: 50 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

University Medical Center Utrecht, Julius Center, Utrecht, , Netherlands

Contact Details

Name: Jantine Schuit, PhD

Affiliation: Dutch Institute of Public Health and the Environment

Role: PRINCIPAL_INVESTIGATOR

Name: Petra HM Peeters, PhD

Affiliation: University Medical Center Utrecht, Julius Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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