Spots Global Cancer Trial Database for Biomarkers in Tissue Samples From Patients With Ductal Breast Carcinoma in Situ

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Trial Identification

Brief Title: Biomarkers in Tissue Samples From Patients With Ductal Breast Carcinoma in Situ

Official Title: A Correlative Science Study for ECOG E5194

Study ID: NCT01132560

Conditions

Breast Cancer

Interventions

RNA analysis

gene expression analysis

reverse transcriptase-polymerase chain reaction

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from patients with ductal breast carcinoma in situ.

Detailed Description: OBJECTIVES: * To validate the prognostic utility of a new ductal breast carcinoma in situ (DCIS) genomic score and the Oncotype DX Recurrence Score® assay in tissue samples from patients with DCIS enrolled on clinical trial ECOG-E5194. OUTLINE: RNA extracted from archived tissue samples are analyzed for gene expression profile by Oncotype DX Recurrence Score® assay (a reverse transcriptase-PCR-based assay).