Spots Global Cancer Trial Database for Prognostic Indicators for Radiation-induced Breast Fibrosis

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Trial Identification

Brief Title: Prognostic Indicators for Radiation-induced Breast Fibrosis

Official Title: Identifying Prognostic Indicators for the Development of Radiation-induced Breast Fibrosis

Study ID: NCT05031065

Conditions

Breast Cancer

Interventions

Breast Cancer Radiotherapy

Study Description

Brief Summary: To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma.

Detailed Description: To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma. Autotaxin and LPA cause fibrosis in other situation, but they have not been tested in radiation-induced fibrosis. We will determine if the duration and magnitude of the autotaxin and LPA responses are prognostic for the 15-28% of patients who will develop fibrosis. This fibrosis will be detected by ultrasound and a novel application of elastography, which should provide much earlier and quantifiable fibrotic changes compared to conventional physical examination.