Spots Global Cancer Trial Database for Effects of High Dose Calcitriol in Breast Cancer Patients

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Trial Identification

Brief Title: Effects of High Dose Calcitriol in Breast Cancer Patients

Official Title: A Pilot Study of the Effects of High-Dose Oral Calcitriol in Breast Cancer Patients Prior to Surgery

Study ID: NCT01293682

Conditions

Breast Cancer

Interventions

Calcitriol

Study Description

Brief Summary: This research will examine the effectiveness of calcitriol in treating bone loss in women who are about to begin treatment for breast cancer. Twenty-five (25) subjects are expected to take part in this study. The investigators don't know if bone loss in breast cancer survivors should be treated differently than bone loss in other women.

Detailed Description: The calcitriol intervention is aimed at reducing fracture risk by maintaining proper bone density. Calcitriol is efficacious in maintaining proper bone health and muscle mass among the general population, but little research has been done on breast cancer patients. In addition, calcitriol may be effective in reducing tumor proliferation and angiogenesis, while increasing tumor apoptosis. Each of those factors could have beneficial effects on breast cancer outcomes.