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Brief Title: Study of Radiation Exposure and Bilateral Breast Cancer
Official Title: Genome-Wide Association Study of Radiation Exposure and Bilateral Breast Cancer
Study ID: NCT00903591
Brief Summary: This study is being done to find out what factors may be related to the risk of getting a second breast cancer among women who already have breast cancer in one breast. It will look at how genes, treatment for breast cancer; including radiation therapy, and the effects of different lifestyle activities, may affect the risk of breast cancer. It will use different processes to find genes that might increase the risk of breast cancer. The results of this study may help to develop better ways to detect, treat and prevent breast cancer. This study will compare women who have breast cancer in both breasts to women who have breast cancer in only one breast.
Detailed Description: This study expands upon an existing case-control study we call the Women's Environment Cancer and Radiation Epidemiology (WECARE) Study. For simplicity, in this protocol, we will refer to that study as the "parent" study. The goal of both studies is to examine the interaction of radiation exposure and genetic susceptibility factors in the etiology of breast cancer. A subset of study participants who consented to 'future contact' in the GWA Study (and those in the 'parent' study from selected sites) will be included in an analysis of radiation-related heart disease and related conditions.
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Stanford University, Stanford, California, United States
University of Iowa, Iowa City, Iowa, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
ONTARIO CANCER REGISTRY, Mount Sinai Hospital, Toronto, Toronto, Ontario, Canada
Danish Cancer Society, København, , Denmark
Name: Jonine Bernstein, PhD
Affiliation: Memorial Sloan Kettering Cancer Center
Role: PRINCIPAL_INVESTIGATOR