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Spots Global Cancer Trial Database for Bone Mineral Density Effects of Zoledronate in Postmenopausal Women With Breast Cancer

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Trial Identification

Brief Title: Bone Mineral Density Effects of Zoledronate in Postmenopausal Women With Breast Cancer

Official Title: Bone Mineral Density Effects of Zoledronate in Postmenopausal Women With Breast Cancer

Study ID: NCT00213980

Conditions

Breast Cancer

Interventions

Zoledronate

Study Description

Brief Summary: This is a two arm, double-blind randomized study looking at the effect of zoledronate, a bisphosphonate, on the bone mineral density (BMD) of postmenopausal women with breast cancer.

Detailed Description: This is a two arm, double-blind randomized study looking at the effect of zoledronate, a bisphosphonate, on the bone mineral density (BMD) of postmenopausal women with breast cancer. An approved bisphosphonate, alendronate, is of benefit in patients with osteoporosis, however, this agent has a roughly 30% incidence of gastrointestinal symptoms and up to 50% of patients may take the drug improperly, compromising absorption and potentially efficacy. Zoledronate is a heterocyclic imidazole third generation bisphosphonate, which is administered intravenously (IV) and has little toxicity. Zoledronate is more potent than alendronate, and because of its route of administration it does not have the problems of poor oral bioavailability and non-compliance.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Wisconsin, Madison, Wisconsin, United States

Contact Details

Name: Daniel Mulkerin, MD

Affiliation: University of Wisconsin, Madison

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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