Spots Global Cancer Trial Database for A Study to Evaluate the Efficacy and Safety of Herceptin® (Trastuzumab) in Combination With Arimidex® (Anastrozole) an Aromatase Inhibitor Compared to Arimidex® Alone in Patients With Metastatic Breast Cancer
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: A Study to Evaluate the Efficacy and Safety of Herceptin® (Trastuzumab) in Combination With Arimidex® (Anastrozole) an Aromatase Inhibitor Compared to Arimidex® Alone in Patients With Metastatic Breast Cancer
Official Title: A Randomized, Open-label Study of the Effect of Herceptin Plus Arimidex Compared With Arimidex Alone on Progression-free Survival in Patients With HER2-positive and Hormone-receptor Positive Metastatic Breast Cancer
Study ID: NCT00022672
Conditions
Study Description
Brief Summary: This 2 arm study assessed the safety and efficacy of adding intravenous trastuzumab (Herceptin®) to daily oral anastrozole (Arimidex®) tablets as first- and second-line treatment in postmenopausal patients with human epidermal growth factor receptor-2 (HER2) overexpressing metastatic breast cancer (ER+ve and/or PR+ve). Patients were randomized to receive either anastrazole 1 mg per os (po) daily, or anastrazole 1 mg po daily + a loading dose of Herceptin® 4 mg/kg intravenous (iv) followed by weekly doses of Herceptin® 2 mg/kg iv. The anticipated time on study treatment was until disease progression, and the target sample size was 100-500 individuals.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
, Phoenix, Arizona, United States
, Little Rock, Arkansas, United States
, Los Angeles, California, United States
, Vallejo, California, United States
, Gainsville, Florida, United States
, Miami, Florida, United States
, Plantation, Florida, United States
, Chicago, Illinois, United States
, Chicago, Illinois, United States
, Kansas City, Kansas, United States
, Scarborough, Maine, United States
, Detroit, Michigan, United States
, Omaha, Nebraska, United States
, Hackensack, New Jersey, United States
, Albuquerque, New Mexico, United States
, Santa Fe, New Mexico, United States
, Rochester, New York, United States
, Cincinnati, Ohio, United States
, Cleveland, Ohio, United States
, Hershey, Pennsylvania, United States
, Box Hill, , Australia
, Darlinghurst, , Australia
, Waratah, , Australia
, Porto Alegre, , Brazil
, Plovdiv, , Bulgaria
, Sofia, , Bulgaria
, Stara Zagora, , Bulgaria
, Calgary, Alberta, Canada
, Edmonton, Alberta, Canada
, Victoria, British Columbia, Canada
, Winnipeg, Manitoba, Canada
, Oshawa, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Montreal, Quebec, Canada
, Quebec City, Quebec, Canada
, Beijing, , China
, Beijing, , China
, Shanghai, , China
, Shanghai, , China
, Wuhan, , China
, Avignon, , France
, Nice, , France
, Frankfurt, , Germany
, Kiel, , Germany
, München, , Germany
, Trier, , Germany
, Hong Kong, , Hong Kong
, Budapest, , Hungary
, Ahmedabad, , India
, Bangalore, , India
, Chennai, , India
, Cuttack, , India
, Ludhiana, , India
, Mumbai, , India
, New Delhi, , India
, New Delhi, , India
, New Delhi, , India
, Haifa, , Israel
, Haifa, , Israel
, Petach Tikva, , Israel
, Ramat-gan, , Israel
, Rehovot, , Israel
, Tel Aviv, , Israel
, Genova, , Italy
, Vilnius, , Lithuania
, Guadalajara, , Mexico
, Mexico City, , Mexico
, Amsterdam, , Netherlands
, Rotterdam, , Netherlands
, Trondheim, , Norway
, Bialystok, , Poland
, Bydgoszcz, , Poland
, Gliwice, , Poland
, Krakow, , Poland
, Lodz, , Poland
, Szczecin, , Poland
, Warszawa, , Poland
, Warszawa, , Poland
, Barnaul, , Russian Federation
, Izhevsk, , Russian Federation
, Kazan, , Russian Federation
, Krasnodar, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, St Petersburg, , Russian Federation
, St Petersburg, , Russian Federation
, St Petersburg, , Russian Federation
, UFA, , Russian Federation
, Floracliffe, , South Africa
, Pretoria, , South Africa
, Barcelona, , Spain
, Córdoba, , Spain
, Girona, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Mataro, , Spain
, Reus, , Spain
, Valencia, , Spain
, Boras, , Sweden
, Gaelve, , Sweden
, Stockholm, , Sweden
, Örebro, , Sweden
, Taipei, , Taiwan
, Taoyuan, , Taiwan
, Ankara, , Turkey
, Ankara, , Turkey
, Istanbul, , Turkey
, Istanbul, , Turkey
, Izmir, , Turkey
, Shhiye, Ankara, , Turkey
, Kiev, , Ukraine
, Kiev, , Ukraine
, Lvov, , Ukraine
, Odessa, , Ukraine
, Sumy, , Ukraine
, Zaporozhye, , Ukraine
, Cardiff, , United Kingdom
, Edinburgh, , United Kingdom
, Guildford, , United Kingdom
, Ipswich, , United Kingdom
, London, , United Kingdom
, London, , United Kingdom
, Manchester, , United Kingdom
, Merseyside, , United Kingdom
, Newcastle Upon Tyne, , United Kingdom
, Southampton, , United Kingdom
, Swansea, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
