Spots Global Cancer Trial Database for A Low AGE (Advanced Glycation End-product) Dietary Intervention for Breast Cancer Survivors
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Trial Identification
Brief Title: A Low AGE (Advanced Glycation End-product) Dietary Intervention for Breast Cancer Survivors
Official Title: A Low AGE (Advanced Glycation End-product) Dietary Intervention for Breast Cancer Survivors
Study ID: NCT05265715
Conditions
Study Description
Brief Summary: The scientific premise for this study is the known impact of overweight/obesity on breast cancer risk and outcomes, the association between advanced glycation end-products (AGE) and high fat, highly processed foods common in Western diets, and the preclinical evidence suggesting a link between AGE and breast cancer independent of weight. The association between dietary and serum AGE in breast cancer survivors and prognosis has not been previously evaluated. However, preclinical studies suggest that AGE may represent a novel, lifestyle-linked, modifiable, prognostic biomarker, which could be targeted through lifestyle (diet and exercise) and/or pharmaceutical interventions to improve breast cancer prognosis. The proposed study will pave the way for a large scale randomized controlled trial to evaluate the impact of a low AGE diet on weight (BMI), known (IL-6 and CRP) and novel (AGE and RAGE) prognostic biomarkers, and ultimately on breast cancer prognosis.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Washington University School of Medicine, Saint Louis, Missouri, United States
Contact Details
Name: Lindsay Peterson, M.D., MSCR
Affiliation: Washington University School of Medicine
Role: PRINCIPAL_INVESTIGATOR
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