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Brief Title: Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women
Official Title: Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer
Study ID: NCT00003906
Brief Summary: RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells. PURPOSE: Randomized double-blinded clinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.
Detailed Description: OBJECTIVES: * Determine whether raloxifene is more or less effective than tamoxifen in significantly reducing the incidence rate of invasive breast cancer in postmenopausal women. * Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart disease, fractures of the hip and spine, or Colles' fractures of the wrist in these participants. * Evaluate the toxic effects of these regimens in these participants. * Determine the effect of these regimens on the quality of life of these participants (at selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.) OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to 49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs 5.0 or greater). Participants are randomized to 1 of 2 arms. * Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years. * Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective 5/31/01.) Participants are followed annually after 5 years. PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5 years.
Minimum Age: 35 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Comprehensive Cancer Institute, Huntsville, Alabama, United States
MBCCOP - Gulf Coast, Mobile, Alabama, United States
Providence Alaska Medical Center, Anchorage, Alaska, United States
CCOP - Western Regional, Arizona, Phoenix, Arizona, United States
CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale, Arizona, United States
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States
Breast Associates, Fayetteville, Arkansas, United States
Surgical Associates, Fort Smith, Arkansas, United States
Northeast Arkansas Clinic, Jonesboro, Arkansas, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Kaiser Permanente Medical Center - Anaheim/Orange County, Anaheim, California, United States
Kaiser Permanente Medical Center - Baldwin Park, Baldwin Park, California, United States
Kaiser Permanente Medical Center - Bellflower, Bellflower, California, United States
Alta Bates Comprehensive Cancer Center, Berkeley, California, United States
Providence Saint Joseph Medical Center - Burbank, Burbank, California, United States
Mills-Peninsula Health Services, Burlingame, California, United States
Enloe Cancer Center at Enloe Medical Center, Chico, California, United States
Mount Diablo Medical Center, Concord, California, United States
Corona Regional Medical Center, Corona, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas, Encinitas, California, United States
North Bay Cancer Center, Fairfield, California, United States
Kaiser Permanente Medical Center - Fontana, Fontana, California, United States
Crosson Cancer Center at St. Jude Medical Center, Fullerton, California, United States
Glendale Memorial Hospital Comprehensive Cancer Center, Glendale, California, United States
Oncology/Hematology Associates, Granada Hills, California, United States
Marin General Hospital Cancer Institute, Greenbrae, California, United States
Kaiser Permanente Medical Center - Harbor City, Harbor City, California, United States
Hemet Valley Medical Center, Hemet, California, United States
Rebecca and John Moores UCSD Cancer Center, La Jolla, California, United States
Valley Tumor Medical Group, Lancaster, California, United States
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda, California, United States
Todd Cancer Institute at Long Beach Memorial Medical Center, Long Beach, California, United States
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach, Long Beach, California, United States
Kaiser Permanente Medical Center - Los Angeles, Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center, Los Angeles, California, United States
Kaiser Foundation Hospital - West Los Angeles, Los Angeles, California, United States
St. Vincent Medical Center - Los Angeles, Los Angeles, California, United States
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
Mission Cancer Center at Mission Hospital, Mission Viejo, California, United States
Sutter Gould Medical Foundation, Modesto, California, United States
Leavey Cancer Center at Northridge Hospital Medical Center, Northridge, California, United States
Breast Health Center, Oceanside, California, United States
St. Joseph Hospital Regional Cancer Center - Orange, Orange, California, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center, Orange, California, United States
Ventura Hematology - Oncology Specialists - Oxnard, Oxnard, California, United States
Comprehensive Cancer Centers of the Desert, Palm Springs, California, United States
Palo Alto Medical Foundation, Palo Alto, California, United States
Kaiser Permanente Medical Group, Panorama City, California, United States
Huntington Cancer Center at Huntington Hospital, Pasadena, California, United States
Wilshire Oncology Medical Group, Incorporated - Pomona, Pomona, California, United States
North Valley Breast Clinic, Redding, California, United States
Kaiser Permanente Medical Center - Riverside, Riverside, California, United States
Sutter Roseville Medical Center, Roseville, California, United States
Sutter Breast Cancer Group, Sacramento, California, United States
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego, California, United States
Naval Medical Center - San Diego, San Diego, California, United States
California Pacific Medical Center - California Campus, San Francisco, California, United States
UCSF Comprehensive Cancer Center, San Francisco, California, United States
Cancer Center of Santa Barbara, Santa Barbara, California, United States
CCOP - Santa Rosa Memorial Hospital, Santa Rosa, California, United States
Stanford Cancer Center at Stanford University Medical Center, Stanford, California, United States
Torrance Memorial Medical Center, Torrance, California, United States
Santa Clarita Valley Cancer Center - UCLA, Valencia, California, United States
Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States
Kaiser Permanente Medical Cener - Woodland Hills, Woodland Hills, California, United States
Penrose Cancer Center, Colorado Springs, Colorado, United States
CCOP - Colorado Cancer Research Program, Incorporated, Denver, Colorado, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
St. Mary-Corwin Regional Medical Center, Pueblo, Colorado, United States
University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center, Farmington, Connecticut, United States
Hartford Hospital, Hartford, Connecticut, United States
St. Francis Hospital and Medical Center, Hartford, Connecticut, United States
Manchester Memorial Hospital, Manchester, Connecticut, United States
Midstate Medical Center, Meriden, Connecticut, United States
New Britain General Hospital, New Britain, Connecticut, United States
Hospital of St. Raphael, New Haven, Connecticut, United States
Yale Comprehensive Cancer Center, New Haven, Connecticut, United States
Lawrence and Memorial Hospital, New London, Connecticut, United States
Eastern Connecticut Hematology and Oncology Associates, Norwich,, Connecticut, United States
Hematology Oncology, P.C., Stamford, Connecticut, United States
Northwestern Connecticut Oncology-Hematology Associates, Torrington, Connecticut, United States
Windham Community Memorial Hospital, Williamantic, Connecticut, United States
Beebe Medical Center, Lewes, Delaware, United States
Nanticoke Memorial Hospital, Seaford, Delaware, United States
CCOP - Christiana Care Health Services, Wilmington, Delaware, United States
Lombardi Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States
Washington Hospital Center, Washington, District of Columbia, United States
Providence Hospital, Washington, District of Columbia, United States
JFK Medical Center, Atlantis, Florida, United States
St. Vincent's Medical Center, Jacksonville, Florida, United States
Baptist Regional Cancer Institute - Jacksonville, Jacksonville, Florida, United States
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter, Florida, United States
Watson Clinic, Lakeland, Florida, United States
Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland, Florida, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
University of Miami Sylvester Cancer Center, Miami, Florida, United States
Florida Hospital Medical Center, Orlando, Florida, United States
MD Anderson Cancer Center Orlando, Orlando, Florida, United States
West Florida Regional Medical Center, Pensacola, Florida, United States
Cancer Research Network Inc., Plantation, Florida, United States
Clinical Research Center of South Florida, Stuart, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Palm Beach Cancer Institute, West Palm Beach, Florida, United States
CCOP - Atlanta Regional, Atlanta, Georgia, United States
Medical College of Georgia, Augusta, Georgia, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah, Georgia, United States
Cancer Care and Research Pavilion at St. Joseph's/Candler, Savannah, Georgia, United States
MBCCOP - Hawaii, Honolulu, Hawaii, United States
North Idaho Cancer Center, Coeur d'Alene, Idaho, United States
Northwest Community Hospital, Arlington Heights, Illinois, United States
Rush Copley Medical Center, Aurora, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States
Northwestern Memorial Hospital, Chicago, Illinois, United States
MBCCOP - University of Illinois at Chicago, Chicago, Illinois, United States
John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois, United States
Rush Cancer Institute at Rush University Medical Center, Chicago, Illinois, United States
Resurrection Medical Center, Chicago, Illinois, United States
Our Lady of the Resurrection Medical Center, Chicago, Illinois, United States
University of Chicago Cancer Research Center, Chicago, Illinois, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States
CCOP - Central Illinois, Decatur, Illinois, United States
Sherman Hospital, Elgin, Illinois, United States
CCOP - Evanston, Evanston, Illinois, United States
St. Francis Hospital, Evanston, Illinois, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Advocate South Suburban Hospital, Hazel Crest, Illinois, United States
Evanston Northwestern Health Care - Highland Park Hospital, Highland Park, Illinois, United States
Hinsdale Hematology Oncology Associates, Hinsdale, Illinois, United States
Joliet Oncology Hematology Associates, Limited - Joliet, Joliet, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States
Edward Hospital Cancer Center, Naperville, Illinois, United States
Mid-Illinois Hematology-Oncology Associates, Normal, Illinois, United States
Advocate Christ Medical Center, Oak Lawn, Illinois, United States
Saint James Hospital and Health Centers Comprehensive Cancer Institute, Olympia Fields, Illinois, United States
Lutheran General Cancer Care Center, Park Ridge, Illinois, United States
CCOP - Illinois Oncology Research Association, Peoria, Illinois, United States
Trinity Medical Center - West, Rock Island, Illinois, United States
Rockford Clinic, Rockford, Illinois, United States
Swedish-American Regional Cancer Center, Rockford, Illinois, United States
Saint Anthony Medical Center, Rockford, Illinois, United States
Edward H. Kaplan MD and Associates, Skokie, Illinois, United States
St. John's Hospital, Springfield, Illinois, United States
Memorial Medical Center, Springfield, Illinois, United States
CCOP - Carle Cancer Center, Urbana, Illinois, United States
Center for Cancer Care at Goshen Health System, Goshen, Indiana, United States
Indiana Community Cancer Care, Incorporated, Indianapolis, Indiana, United States
Methodist Cancer Center at Methodist Hospital, Indianapolis, Indiana, United States
Indiana Regional Cancer Center, Indianapolis, Indiana, United States
St. Vincent Hospital and Health Care Center, Indianapolis, Indiana, United States
Oncology Institute of Greater Lafayette, Lafayette, Indiana, United States
Saint Anthony Memorial Health Centers, Michigan City, Indiana, United States
Ball Memorial Hospital Cancer Center, Muncie, Indiana, United States
Community Hospital, Munster, Indiana, United States
CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States
McFarland Clinic, P.C., Ames, Iowa, United States
CCOP - Cedar Rapids Oncology Project, Cedar Rapids, Iowa, United States
Medical Associates, Clinton, Iowa, United States
Jennie Edmundson Memorial Hospital, Council Bluffs, Iowa, United States
Genesis Regional Cancer Center at Genesis Medical Center, Davenport, Iowa, United States
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
Wendt Regional Cancer Center of Finley Hospital, Dubuque, Iowa, United States
Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City, Iowa, United States
Ottumwa Regional Health Center, Ottumwa, Iowa, United States
Siouxland Hematology-Oncology, Sioux City, Iowa, United States
Cedar Valley Medical Specialists, P.C., Waterloo, Iowa, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City, Kansas, United States
CCOP - Wichita, Wichita, Kansas, United States
King's Daughters Medical Center, Ashland, Kentucky, United States
St. Elizabeth Medical Center, Edgewood, Kentucky, United States
HCA Kings Daughters Memorial Hospital, Frankfort, Kentucky, United States
Central Baptist Hospital, Lexington, Kentucky, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington, Kentucky, United States
Norton Healthcare Cancer Center, Louisville, Kentucky, United States
James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States
Baptist Hospital East - Louisville, Louisville, Kentucky, United States
Ochsner Clinic of Baton Rouge, Baton Rouge, Louisiana, United States
Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States
Cancer Care Specialists, Houma, Louisiana, United States
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States
Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans, Louisiana, United States
CCOP - Ochsner, New Orleans, Louisiana, United States
Cancer Treatment Center at Christus Schumpert St. Mary Place, Shreveport, Louisiana, United States
Eastern Maine Medical Center, Bangor, Maine, United States
Goodall Hospital, Sanford, Maine, United States
Maine Center for Cancer Medicine and Blood Disorders - Scarborough, Scarborough, Maine, United States
Anne Arundel Medical Center, Annapolis, Maryland, United States
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States
Greater Baltimore Medical Center and Cancer Center, Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Franklin Square Hospital Center, Baltimore, Maryland, United States
Suburban Hospital, Bethesda, Maryland, United States
Frederick Memorial Hospital Regional Cancer Therapy Center, Frederick, Maryland, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts, United States
Cancer Research Center at Boston Medical Center, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Harvard Vanguard Medical Associates - Kenmore, Boston, Massachusetts, United States
Lahey Clinic Medical Center - Burlington, Burlington, Massachusetts, United States
Saint Anne's Hospital, Fall River, Massachusetts, United States
Caritas Norwood Hospital, Norfolk, Massachusetts, United States
NSMC Cancer Center, Peabody, Massachusetts, United States
Berkshire Physicians and Surgeons, P.C., Pittsfield, Massachusetts, United States
Jordan Hospital Club Cancer Center, Plymouth, Massachusetts, United States
Baystate Regional Cancer Program at Baystate Medical Center, Springfield, Massachusetts, United States
University of Massachusetts Memorial Medical Center - University Campus, Worcester, Massachusetts, United States
Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan, United States
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Battle Creek Health System, Battle Creek, Michigan, United States
Bay Diagnostic Center for Women, Bay City, Michigan, United States
Community Health Center of Branch County, Coldwater, Michigan, United States
Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit, Michigan, United States
St. John Hospital and Medical Center, Detroit, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Flint Hematology Oncology, Flint, Michigan, United States
Genesys Regional Medical Center, Grand Blanc, Michigan, United States
CCOP - Grand Rapids, Grand Rapids, Michigan, United States
Holland Community Hospital, Holland, Michigan, United States
Center for Hematology/Oncology, Jackson, Michigan, United States
CCOP - Kalamazoo, Kalamazoo, Michigan, United States
Michigan State University Department of Surgery, Lansing, Michigan, United States
Lapeer Regional Hospital, Lapeer, Michigan, United States
Marquette General Hospital, Marquette, Michigan, United States
Mercy Memorial Hospital, Corporation, Monroe, Michigan, United States
Community Cancer Care Specialist, Mount Clemens, Michigan, United States
Memorial Healthcare, Owosso, Michigan, United States
Blue Water Oncology PC, Port Huron, Port Huron, Michigan, United States
CCOP - Beaumont, Royal Oak, Michigan, United States
Saint Mary's Seton Cancer Institute, Saginaw, Michigan, United States
Providence Cancer Institute at Providence Hospital, Southfield, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
St. John Macomb Hospital, Warren, Michigan, United States
CCOP - Duluth, Duluth, Minnesota, United States
St. Luke's Medical Clinic, Duluth, Minnesota, United States
Minnesota Cooperative Group Program, Minneapolis, Minnesota, United States
Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States
University of Minnesota, Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Rice Memorial Hospital, Willmar, Minnesota, United States
Coast Oncology/Hematology, P.L.L.C., Biloxi, Mississippi, United States
Mid Delta Family Practice, Cleveland, Mississippi, United States
Hattiesburg Clinic, P.A., Hattiesburg, Mississippi, United States
Jackson Oncology Associates, PLLC, Jackson, Mississippi, United States
Keesler Medical Center - Keesler Air Force Base, Keesler AFB, Mississippi, United States
North Mississippi Hematology and Oncology Associates, Limited, Tupelo, Mississippi, United States
Saint Luke's Hospital, Chesterfield, Missouri, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia, Missouri, United States
Freeman Cancer Institute at Freeman Health System, Joplin, Missouri, United States
St. John's Regional Medical Center, Joplin, Missouri, United States
CCOP - Kansas City, Kansas City, Missouri, United States
Phelps County Regional Medical Center, Rolla, Missouri, United States
Midwest Hematology Oncology Group, Inc., Saint Louis, Missouri, United States
Siteman Cancer Center, Saint Louis, Missouri, United States
Missouri Baptist Cancer Center, Saint Louis, Missouri, United States
CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri, United States
St. John's Regional Health Center, Springfield, Missouri, United States
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States
Missouri Cancer Care, P.C. - St. Charles, St. Charles, Missouri, United States
Ozarks Medical Center, West Plains, Missouri, United States
CCOP - Montana Cancer Consortium, Billings, Montana, United States
Montana Cancer Institute - Benefis Healthcare, Great Falls, Montana, United States
Kalispell Regional Medical Center, Kalispell, Montana, United States
Saint Francis Medical Center, Grand Island, Nebraska, United States
Cancer Center at the Good Samaritan Health Systems, Kearney, Nebraska, United States
Cancer Resource Center - Lincoln, Lincoln, Nebraska, United States
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha, Nebraska, United States
Alegent Health - Immanuel Medical Center, Omaha, Nebraska, United States
Bergan Mercy Medical Center, Omaha, Nebraska, United States
Creighton University Medical Center, Omaha, Nebraska, United States
CCOP - Southern Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
New Hampshire Oncology-Hematology, PA - Hooksett, Hooksett, New Hampshire, United States
Southern New Hampshire Medical Center, Nashua, New Hampshire, United States
Cooper Cancer Institute, Camden, New Jersey, United States
Englewood Hospital and Medical Center, Englewood, New Jersey, United States
Hunterdon Regional Cancer Center, Flemington, New Jersey, United States
CCOP - Northern New Jersey, Hackensack, New Jersey, United States
St. Barnabas Medical Center, Livingston, New Jersey, United States
Monmouth Medical Center, Long Branch, New Jersey, United States
South Jersey Regional Cancer Center, Millville, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly, New Jersey, United States
Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Newark Beth Israel Medical Center, Newark, New Jersey, United States
Warren Hospital, Phillipsburg, New Jersey, United States
Atlantic City Medical Center, Pomona, New Jersey, United States
Booker Cancer Center at Riverview Medical Center, Red Bank, New Jersey, United States
Valley Hospital, Ridgewood, New Jersey, United States
Somerset Medical Center, Somerville, New Jersey, United States
Community Medical Center, Toms River, New Jersey, United States
Capital Health System at Mercer, Trenton, New Jersey, United States
Underwood Memorial Hospital, Woodbury, New Jersey, United States
Hematology-Oncology Associates, PC, Albuquerque, New Mexico, United States
Lovelace Medical Center at Lovelace Sandia Health System, Albuquerque, New Mexico, United States
New Mexico Oncology-Hematology Consultants, Limited, Albuquerque, New Mexico, United States
University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico, United States
New Mexico Cancer Care Associates, Santa Fe, New Mexico, United States
New York Oncology Hematology, P.C. - Albany Regional Cancer Center, Albany, New York, United States
Albert Einstein Clinical Cancer Center, Bronx, New York, United States
Comprehensive Cancer Center at Our Lady of Mercy Medical Center, Bronx, New York, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital, Cooperstown, New York, United States
Charles R. Wood Foundation Cancer Center at Glens Falls Hospital, Glens Falls, New York, United States
Queens Cancer Center of Queens Hospital, Jamaica, New York, United States
New York Oncology Hematology, P.C. - Latham, Latham, New York, United States
CCOP - North Shore University Hospital, Manhasset, New York, United States
Saint Vincent Catholic Medical Center of New York, New York, New York, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York, United States
St. Francis Hospital and Health Centers, Poughkeepsie, New York, United States
Vassar Brothers Medical Center, Poughkeepsie, New York, United States
Genesee Surgical Associates, Rochester, New York, United States
Gynecologic Oncology Associates, Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States
University Hospital - Stony Brook, Stony Brook, New York, United States
University Hospital at State University of New York - Upstate Medical University, Syracuse, New York, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse, New York, United States
Mission Hospitals, Asheville, North Carolina, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, United States
Presbyterian Healthcare, Charlotte, North Carolina, United States
Duke Comprehensive Cancer Center, Durham, North Carolina, United States
Cape Fear Valley Health System, Fayetteville, North Carolina, United States
Gaston Hematology and Oncology, Gastonia, North Carolina, United States
Southeastern Medical Oncology Center, Goldsboro, North Carolina, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro, North Carolina, United States
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville, North Carolina, United States
Pardee Memorial Hospital, Hendersonville, North Carolina, United States
Cornerstone Surgery, High Point, North Carolina, United States
Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center, Raleigh, North Carolina, United States
Cancer Center at Iredell Memorial Hospital, Statesville, North Carolina, United States
New Hanover Regional Medical Center, Wilmington, North Carolina, United States
Forsyth Medical Center, Winston-Salem, North Carolina, United States
CCOP - Southeast Cancer Control Consortium, Winston-Salem, North Carolina, United States
Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States
Quain & Ramstad Clinic, Bismarck, North Dakota, United States
CCOP - Merit Care Hospital, Fargo, North Dakota, United States
Akron General Medical Center, Akron, Ohio, United States
Mercy Medical Center, Canton, Ohio, United States
Aultman Hospital Cancer Center at Aultman Health Foundation, Canton, Ohio, United States
Cancer Center at Christ Hospital, Cincinnati, Ohio, United States
Bethesda North Hospital, Cincinnati, Ohio, United States
Charles M. Barrett Cancer Center at University Hospital, Cincinnati, Ohio, United States
Ireland Cancer Center, Cleveland, Ohio, United States
Fairview Hospital, Cleveland, Ohio, United States
Kaiser Permanente, Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
CCOP - Columbus, Columbus, Ohio, United States
Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, United States
Blanchard Valley Medical Associates, Findlay, Ohio, United States
Fremont Memorial Hospital, Fremont, Ohio, United States
Cleveland Clinic Cancer Center, Independence, Ohio, United States
CCOP - Dayton, Kettering, Ohio, United States
Lima Memorial Hospital, Lima, Ohio, United States
St. Luke's Hospital, Maumee, Ohio, United States
Parma Community General Hospital, Parma, Ohio, United States
Firelands Regional Medical Center, Sandusky, Ohio, United States
Flower Hospital - ProMedica Health System, Sylvania, Ohio, United States
Toledo Hospital, Toledo, Ohio, United States
St. Vincent Mercy Medical Center, Toledo, Ohio, United States
Medical College of Ohio Cancer Institute, Toledo, Ohio, United States
St. Charles Hospital, Toledo, Ohio, United States
CCOP - Toledo Community Hospital, Toledo, Ohio, United States
Toledo Clinic, Incorporated, Toledo, Ohio, United States
Cleveland Clinic Health System STAR BCPT, Warrensville Heights, Ohio, United States
Fulton County Health Center, Wauseon, Ohio, United States
Muskogee Regional Medical Center, Muskogee, Oklahoma, United States
Frank C. Love Cancer Institute at St. Anthony Hospital, Oklahoma City, Oklahoma, United States
Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center, Oklahoma City, Oklahoma, United States
Mercy Health Center, Oklahoma City, Oklahoma, United States
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
St. John Health System, Tulsa, Oklahoma, United States
CCOP - Oklahoma, Tulsa, Oklahoma, United States
St. Charles Medical Center, Bend, Oregon, United States
Cancer Institute at Oregon Health and Science University, Portland, Oregon, United States
CCOP - Columbia River Oncology Program, Portland, Oregon, United States
Kaiser Permanente Center for Health Research, Portland, Oregon, United States
Abington Memorial Hospital, Abington, Pennsylvania, United States
Sacred Heart Hospital, Allentown, Pennsylvania, United States
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown, Pennsylvania, United States
Bon Secours-Holy Family Health System, Altoona, Pennsylvania, United States
St. Luke's Hospital Cancer Center, Bethlehem, Pennsylvania, United States
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States
Geisinger Medical Center, Danville, Pennsylvania, United States
Mercy Fitzgerald Hospital, Darby, Pennsylvania, United States
Doylestown Hospital, Doylestown, Pennsylvania, United States
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States
Easton Hospital, Easton, Pennsylvania, United States
Ephrata Community Hopital, Ephrata, Pennsylvania, United States
Regional Cancer Center - Erie, Erie, Pennsylvania, United States
Pinnacle Health Regional Cancer Center at Pinnacle Health System, Harrisburg, Pennsylvania, United States
Mercy Community Hospital, Havertown, Pennsylvania, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Lancaster General Hospital, Lancaster, Pennsylvania, United States
Saint Mary Regional Cancer Center, Langhorne, Pennsylvania, United States
Riddle Memorial Hospital, Media, Pennsylvania, United States
Cancer Center at Paoli Memorial Hospital, Paoli, Pennsylvania, United States
Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States
Pennsylvania Oncology Hematology Associates, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Frankford Hospital, Philadelphia, Pennsylvania, United States
Chestnut Hill Healthcare, Philadelphia, Pennsylvania, United States
Fox Chase - Temple Cancer Center, Philadelphia, Pennsylvania, United States
Albert Einstein Cancer Center, Philadelphia, Pennsylvania, United States
Mercy Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Allegheny General Hospital, Pittsburgh, Pennsylvania, United States
Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States
Pottstown Memorial Regional Cancer Center, Pottstown, Pennsylvania, United States
Reading Hospital and Medical Center, Reading, Pennsylvania, United States
Grand View Hospital, Sellersville, Pennsylvania, United States
Crozer-Chester Medical Center, Upland, Pennsylvania, United States
Chester County Hospital, West Chester, Pennsylvania, United States
Lankenau Cancer Center at Lankenau Hospital, Wynnewood, Pennsylvania, United States
Wellspan Health - York Cancer Center, York, Pennsylvania, United States
Rhode Island Hospital, Providence, Rhode Island, United States
AnMed Health, Anderson, South Carolina, United States
Roper St. Francis Healthcare - Roper Hospital, Charleston, South Carolina, United States
Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States
Palmetto Richland Memorial Hospital, Columbia, South Carolina, United States
McLeod Regional Medical Center, Florence, South Carolina, United States
Cancer Centers of the Carolinas - Eastside, Greenville, South Carolina, United States
CCOP - Upstate Carolina, Spartanburg, South Carolina, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
CCOP - Sioux Community Cancer Consortium, Sioux Falls, South Dakota, United States
Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
U.T. Cancer Institute at University of Tennessee Medical Center, Knoxville, Tennessee, United States
Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis, Memphis, Tennessee, United States
MBCCOP - Meharry Medical College - Nashville, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center, Nashville, Tennessee, United States
Hendrick Cancer Center, Abilene, Texas, United States
Harrington Cancer Center, Amarillo, Texas, United States
Julie and Ben Rogers Cancer Center, Beaumont, Texas, United States
Presbyterian Hospital of Dallas, Dallas, Texas, United States
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States
Charles A. Sammons Cancer Center, Dallas, Texas, United States
Methodist Dallas Medical Center, Dallas, Texas, United States
Providence Memorial Hospital, El Paso, Texas, United States
Harris Methodist Fort Worth, Fort Worth, Texas, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Baylor College of Medicine, Houston, Texas, United States
Texas Cancer Institute at St. Luke's Episcopal Hospital, Houston, Texas, United States
Baylor Medical Center at Garland, Irving, Texas, United States
Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States
Sanchez Cancer Center, Laredo, Texas, United States
Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States
Southwest Cancer and Research Center at University Medical Center, Lubbock, Texas, United States
Memorial Health System of East Texas, Lufkin, Texas, United States
Baylor/Richardson Cancer Center, Richardson, Texas, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
CCOP - Scott and White Hospital, Temple, Texas, United States
University of Texas Health Center at Tyler, Tyler, Texas, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Green Mountain Oncology Group, Bennington, Vermont, United States
Southwestern Vermont Regional Cancer Center, Bennington, Vermont, United States
Mountainview Medical, Berlin, Vermont, United States
Vermont Cancer Center at University of Vermont, Burlington, Vermont, United States
Community Cancer Center at Rutland Regional Medical Center, Rutland, Vermont, United States
Martha Jefferson Hospital, Charlottesville, Virginia, United States
Cancer Center of the Piedmont, Inc., Danville, Virginia, United States
Danville Hematology and Oncology, Incorporated, Danville, Virginia, United States
Virginia Oncology Associates - Newport News, Newport News, Virginia, United States
Henrico Doctors' Hospital - Parham Campus, Richmond, Virginia, United States
MBCCOP - Massey Cancer Center, Richmond, Virginia, United States
Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia, United States
St. Joseph Hospital Community Cancer Center, Bellingham, Washington, United States
Olympic Hematology and Oncology, Bremerton, Washington, United States
Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus, Everett, Washington, United States
CCOP - Virginia Mason Research Center, Seattle, Washington, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Cancer Care Northwest - Spokane North, Spokane, Washington, United States
Rockwood Clinic P.S., Spokane, Washington, United States
CCOP - Northwest, Tacoma, Washington, United States
Yakima Regional Cancer Care Center, Yakima, Washington, United States
David Lee Cancer Center at Charleston Area Medical Center, Charleston, West Virginia, United States
Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, United States
CCOP - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States
Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States
Oncology Alliance, S.C., Milwaukee, Wisconsin, United States
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States
Waukesha Memorial Hospital Regional Cancer Center, Waukesha, Wisconsin, United States
UW Cancer Center Wausau Hospital, Wausau, Wisconsin, United States
Tom Baker Cancer Center - Calgary, Calgary, Alberta, Canada
Cross Cancer Institute, Edmonton, Alberta, Canada
University Hospital - U.B.C. Site, Vancouver, British Columbia, Canada
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Familial Oncology Program, Kingston, Ontario, Canada
Credit Valley Hospital, Mississauga, Ontario, Canada
North York General Hospital, Ontario, North York, Ontario, Canada
Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
Northwestern Ontario Regional Cancer Care, Thunder Bay, Ontario, Canada
Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
St. Michael's Hospital - Toronto, Toronto, Ontario, Canada
Toronto General Hospital, Toronto, Ontario, Canada
Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center, Toronto, Ontario, Canada
CHUS-Hopital Fleurimont, Fleurimont, Quebec, Canada
Hopital Charles Lemoyne, Greenfield Park, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
Royal Victoria Hospital - Montreal, Montreal, Quebec, Canada
Montreal General Hospital, Montreal, Quebec, Canada
Ville Marie Breast Center, Montreal, Quebec, Canada
Jewish General Hospital - Montreal, Montreal, Quebec, Canada
Hopital du Saint-Sacrement, Quebec, Quebec City, Quebec, Canada
Centre Universitaire de Sante de L'Estrie, Sherbrooke, Quebec, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada
MBCCOP - San Juan, San Juan, , Puerto Rico
Name: Norman Wolmark, MD
Affiliation: NSABP Foundation Inc
Role: STUDY_CHAIR