Spots Global Cancer Trial Database for Molecular Imaging of Breast Cancer With Breast PET/CT

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Trial Identification

Brief Title: Molecular Imaging of Breast Cancer With Breast PET/CT

Official Title: Molecular Imaging of Breast Cancer With Breast PET/CT

Study ID: NCT00584753

Conditions

Breast Cancer

Interventions

Positron emission tomography and computed tomography

Study Description

Brief Summary: This study is a feasibility study to determine if a combined breast PET/CT scanner can image malignant functional activity while determining anatomical structure in the same clinical setting for patients with breast cancer. End-points of this study are whether women will accept the imaging position and timing, and whether functional properties of breast cancer can be imaged with this device. The secondary purpose of this study is to explore protocol parameters with a view to optimizing imaging performance whilst minimizing patient discomfort. Imaging results will be compared to histological samples to determine ground truth.

Detailed Description: PET is literally a molecular imaging modality. In monitoring the patient's response to a specific chemotherapeutic regime, baseline and subsequent PET/CT scans can be used to quantitatively determine the therapeutic effect of the regime, using the standard uptake value (SUV), a common metric in PET imaging. The breast PET/CT system will facilitate molecular imaging of breast cancer using a number of radiolabeled molecules, available both commercially (18-FDG) and from the research environment.